Association between erythropoietin requirements and antihypertensive agents.

Background: Angiotensin-converting enzyme inhibitors (ACI) and angiotensin II receptor blockers (ARB) have been reported to increase recombinant human erythropoietin (rHuEPO) requirements. We performed a cross-sectional study to investigate an association of antihypertensive agents including these two with the rHuEPO dose in chronic hemodialysis patients.

Methods: We studied 625 patients undergoing hemodialysis therapy in 11 dialysis units.