The outcomes of surgical repairs of vesicovaginal fistula in 16 patients.

We retrospectively analysed 16 patients who underwent surgical repair for vesicovaginal fistula (VVF) in our department from 1995 to 2012. A total of 14 patients (88%) were cured after the primary repair and two patients were cured by reoperation. We compared the characteristics of the patients whose VVF occurred early and late after surgery.

Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer--results from phase I clinical trials.

We previously identified a human leukocyte antigen (HLA)-A24-restricted antigenic peptide, survivin-2B80-88, a member of the inhibitor of apoptosis protein family, recognized by CD8+cytotoxic T lymphocytes (CTL). In a phase I clinical trial of survivin-2B80-88 vaccination for metastatic urothelial cancer (MUC), we achieved clinical and immunological responses with safety. Moreover, our previous study indicated that interferon alpha (IFN α ) enhanced the effects of the vaccine for colorectal cancer.

Clinical significance of definite muscle layer in TUR specimen for evaluating progression rate in T1G3 bladder cancer: multicenter retrospective study by the Sapporo Medical University Urologic Oncology Consortium (SUOC).

Purpose: To evaluate the clinical impact on progression and recurrence according to presence and absence of a muscle layer, we conducted a retrospective, multicenter study.

Methods: We retrospectively reviewed 247 patients who received transurethral resection (TUR) of bladder tumors and were pathologically diagnosed as having T1G3 bladder cancer from 1990 to 2009. We ruled out 8 patients who received immediate cystectomy and analyzed the remaining 239 T1G3 patients.

[Clinical and pathological features of the best candidates for active surveillance-retrospective analysis of patients with radical prostatectomy].

To develop a more clinically relevant protocol and identify the best candidates for active surveillance (AS), we examined the pathological features of radical prostatectomy (RP) specimens of patients who met the Japanese AS protocol criteria. Of 342 patients who underwent RP between 2000 and 2010, 58 (17.0%) eligible for the Japanese AS protocol were retrospectively identified.

Prognostic factors of patients with metastatic renal cell carcinoma with removed metastases: a multicenter study of 556 patients.

Objective: To investigate the prognosis and prognostic factors of patients with metastatic renal cell carcinoma who underwent metastasectomy.

Methods: We sent questionnaires to Japanese hospitals. The questionnaires included data of patients with metastatic renal cell carcinoma who had their metastatic lesions removed between January 1988 and December 2009.

[A case of IgG4-related kidney disease mimicking a renal cell carcinoma].

A 56-year-old man who had a 28mm renal mass on computed tomography (CT) pointed out at another hospital visited our department. The tumor was buried and located in the renal hilus, which was slightly enhanced in the early phase and washed out in the delayed phase. We diagnosed it as papillary renal cell carcinoma and conducted partial nephrectomy.

Clinicopathological analysis of patients with non-muscle-invasive bladder cancer: prognostic value and clinical reliability of the 2004 WHO classification system.

Objective: The aim of this study was to clarify the prognostic value and clinical reliability of the 2004 World Health Organization classification system of non-muscle-invasive bladder cancer.

Methods: Between January 1995 and November 2010, 153 patients were diagnosed with non-muscle-invasive bladder cancer. We used a substage system that discerns T1-microinvasive (T1m, 42 patients) and T1-extensive-invasive (T1e, 37 patients) cancers.

Clinical efficacy and safety of imidafenacin as add-on treatment for persistent overactive bladder symptoms despite α-blocker treatment in patients with BPH: the ADDITION study.

Objective: To evaluate the effects of add-on treatment with an anticholinergic (imidafenacin) on persistent overactive bladder (OAB) symptoms despite α-blocker (tamsulosin) treatment in patients with benign prostatic hyperplasia (BPH).

Methods: Patients with BPH ≥50 years old, with urinary urgency at least once per week and total OAB symptom score (OABSS) ≥3 points after ≥8-week treatment with tamsulosin were enrolled in a multicenter, open-label study (not double-blinded). Patients were randomized to receive tamsulosin (0.

Olanzapine for the prevention of chemotherapy-induced nausea and vomiting in patients receiving highly or moderately emetogenic chemotherapy: a randomized, double-blind, placebo-controlled study.

Context: Chemotherapy-induced nausea and vomiting (CINV) can severely impair patients' quality of life (QOL). Psychotropics, especially olanzapine, have a strong antiemetic effect.

Objectives: To determine whether olanzapine could reduce the frequency of CINV and improve patients' QOL during chemotherapy.

[A case of metastatic renal cell carcinoma with no evidence of disease for a long term after a favorable response to molecular-targeted therapy followed by metastasectomy].

We report a case of metastatic renal cell carcinoma (RCC) treated with cytoreductive nephrectomy, cytokine therapy, and molecular targeted therapy followed by metastasectomy. A 47-year-old man was diagnosed as having bilateral RCC with metastases to the lung, liver, left adrenal gland, and lymph nodes in the mediastinum. He initially received right radical nephrectomy, left partial nephrectomy, and left adrenalectomy.

Establishment of an ASPL-TFE3 renal cell carcinoma cell line (S-TFE).

Xp11 translocation renal cell carcinoma is a rare disease diagnosed in children and adolescents in the advanced stage with an aggressive clinical course. Various gene fusions including the transcription factor E3 (TFE3) gene located on chromosome X cause the tumor. We established an Xp11 translocation renal cell carcinoma cell line from a renal tumor in a 18-y-old Japanese female and named it "S-TFE.

[Issues associated with sexual development during adolescence: from urological perspectives].

"Sex" is defined by several factors, such as chromosomes, gonads, and internal and external genitalia. Males basically have a Y chromosome and testes. The testis produces and secretes Mullerian inhibiting substance and testosterone.

Adrenal hemorrhagic pseudocyst as the differential diagnosis of pheochromocytoma--a review of the clinical features in cases with radiographically diagnosed pheochromocytoma.

Background: Clinical diagnosis of pheochromocytoma is difficult for some adrenal tumors.

Aim: Herein, we review clinical and pathological findings of 31 cases with radiographically diagnosed pheochromocytoma, including three cases of hemorrhagic pseudocysts (HPC).

Materials/subjects And Methods: Between January 1992 and December 2010, 31 patients with adrenal tumors were pre-operatively diagnosed as having pheochromocytoma by radiographic imaging, and underwent adrenalectomy.

[A case of stromal tumors of uncertain malignant potential treated by radical prostatectomy].

A 56-year-old man visited a local hospital after experiencing urinary frequency for five years. A digital rectal examination revealed a markedly enlarged prostate and his serum prostate specific antigen (PSA) was 9.0 ng/ml.

Influence of isoflavone intake and equol-producing intestinal flora on prostate cancer risk.

Background: The age-adjusted incidence rate of prostate cancer (PCa) has been reported to be lower among Asians than Western populations. A traditional Japanese meal, high in soybean products or isoflavones, may be associated with a decreased risk of PCa. Equol, which is converted from daidzein by human intestinal flora, is biologically more active than any other isoflavone aglycone.

Impact of pre-treatment prostate tissue androgen content on the prediction of castration-resistant prostate cancer development in patients treated with primary androgen deprivation therapy.

Great advances in tissue androgen analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) have made it possible to evaluate the tissue androgen content from a single needle prostate biopsy specimen. In this study, we investigated if pre-treatment androgen content in prostate biopsy specimens could predict their response to primary androgen deprivation therapy (ADT) and future castration-resistant prostate cancer (CRPC). One-hundred and sixty-five prostate cancer patients who received primary ADT were enrolled.

[A case of squamous cell carcinoma of the bladder in a patient with interstitial cystitis].

A 60-year-old woman with interstitial cystitis (IC), who had previously received hydrodistention surgery, intravesical instillation of resiniferatoxin and medication, was being followed. Although urinary cytology was regularly tested with no positive findings, computed tomography carried out for screening of recurrent colon cancer showed muscle-invasive squamous cell carcinoma (SCC) of the bladder (cT3bN0M0). Cystectomy was performed, but she died due to rapid disease progression at 3 months postoperatively.

Evaluation of long-term outcome for patients with renal cell carcinoma after surgery: analysis of cancer deaths occurring more than 10 years after initial treatment.

Objective: We evaluated the outcome of renal cell carcinoma (RCC) after surgery in a long-term follow-up study to elucidate the specific biological behaviors of RCC, such as late recurrence and late cancer-specific death.

Materials And Methods: We retrospectively reviewed the clinical and pathological features of 625 patients who were diagnosed as having renal cell carcinoma at our institution from 1975 to 2006. We analyzed the parameters and outcomes for the patients who had received radical or partial nephrectomy.

Long-term safety, efficacy, and tolerability of imidafenacin in the treatment of overactive bladder: a review of the Japanese literature.

Imidafenacin is an antimuscarinic agent with high affinity for the M(3) and M(1) muscarinic receptor subtypes and low affinity for the M(2) subtype, and is used to treat overactive bladder. Several animal studies have demonstrated that imidafenacin has organ selectivity for the bladder over the salivary glands, colon, heart, and brain. In Phase I studies in humans, the approximately 2.

Long-term outcome of small, organ-confined renal cell carcinoma (RCC) is not always favourable.

Unlabelled: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Small, organ-confined renal cell carcinoma (RCC) generally has favourable pathological characteristics and a good prognosis. However, late recurrence is a known characteristic of the biological behaviour of RCC and no consensus has been established for surveillance protocols from 5 years after radical or partial nephrectomy. In the present study with long-term follow-up of patients with small RCCs, 18 of 172 patients (10.

Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor.

Prostate cancer cells include a small population of cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) that have roles in initiation and progression of the cancer. Recently, we isolated prostate CSCs/CICs as aldehyde dehydrogenase 1-highh (ALDH1(high) ) cells using the ALDEFLUOR assay; however, the molecular mechanisms of prostate CSCs/CICs are still elusive. Prostate CSCs/CICs were isolated as ALDH1(high) cells using the ALDEFLUOR assay, and the gene expression profiles were analyzed using a cDNA microarray and RT-PCR.

Clinical outcomes of urothelial carcinoma of the prostate detected in radical cystectomy specimens.

Background: To evaluate the clinical outcomes of urothelial carcinoma of the prostate (UCP).

Materials And Methods: This retrospective study included a total of 46 patients with UCP detected in radical cystectomy specimens from 1990 to 2006. All patients were stratified by patterns for extension of UC from the bladder and invasion of the prostatic stroma.