Publications by authors named "Masumi Tanaka"
Transcranial Magnetic Stimulation-Electroencephalography (TMS-EEG) is a non-operative technique that allows for magnetic cortical stimulation (TMS) and analysis of the electrical currents generated in the brain (EEG). Despite the regular utilization of both techniques independently, little is known about the potential impact of their combination in neurosurgical practice. This scoping review, conducted following PRISMA guidelines, focused on TMS-EEG in epilepsy, neuro-oncology, and general neurosurgery.
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- * In this case, instead of immediately extubating the patient, they were given noninvasive positive-pressure ventilation (NPPV) through NT, which helped reduce respiratory effort and afterload.
- * The patient's vital signs remained stable post-extubation, allowing for eventual weaning off NPPV and transfer to a general ward, showcasing the NT's benefits in managing severe heart failure.
Background/aim: Invasive ductal carcinoma (IDC) is classified into distinct subtypes with varying prognoses and treatment sensitivities. For instance, triple-negative breast cancer (TNBC) is associated with poorer outcomes than other subtypes. We have previously reported the role of interstitial CD73 in tumor invasion and its correlation with prognosis in other cancers.
View Article and Find Full Text PDFBackground: Nipple adenoma is a relatively rare benign disease. Clinically, it often presents with nipple erosions, and it should be differentiated from Paget's disease.
Case Presentation: The patient was a 63-year-old woman who complained of a lump in her left nipple for more than 30 years.
Article Synopsis
- DYRK2 is a kinase that affects the degradation of TERT, a protein linked to cancer, and this study explored their expressions in breast cancer patients to predict recurrence.
- The analysis involved 221 early breast cancer patients, and researchers used immunohistochemical methods to examine DYRK2 and TERT levels and their relationship to clinical outcomes.
- Findings showed that DYRK2 positivity was linked to better disease-free survival, while TERT positivity indicated worse survival; combining both markers may help better classify breast cancer patients.
Article Synopsis
- A 40-year-old woman had a right breast mass for a year, which grew larger, leading to a diagnosis of Stage ⅢC triple-negative breast cancer.
- She received 4 courses of EC therapy followed by 7 courses of paclitaxel plus bevacizumab before being referred for surgical intervention.
- After a successful right mastectomy and related surgeries, she experienced a good recovery and improved quality of life, indicating the effectiveness of the combined treatment approach for her condition.
Febrile neutropenia(FN)is an adverse event associated with chemotherapy. Because well-maintained dose intensity improves survival rate, suppression of FN is important. While the incidence of FN has been recognized to be higher with docetaxel/cyclophosphamide(TC)therapy, it is generally considered lower with doxorubicin/cyclophosphamide(AC)therapy, and primary prophylaxis with granulocyte-colony stimulating factor(G-CSF)is not recommended.
View Article and Find Full Text PDFThe time courses of interleukin (IL)-6 gene expression and protein production were examined in human pulmonary artery endothelial cells (HPAECs) subjected to cyclic stretching. IL-6 protein was increased even in cells without stretching. Fold changes determined by dividing the level of IL-6 protein in stretched cells by that in unstretched cells at the same sampling times indicated that IL-6 protein was increased by stretching.
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- The SCG/Kj mouse model mimics human crescentic glomerulonephritis and vasculitis, characterized by the production of MPO-ANCA autoantibodies, primarily influenced by the lpr mutation of the Fas gene and additional non-Fas genetic factors.
- Genome-wide QTL mapping on intercross mice identified 14 non-Fas QTLs linked to various disease characteristics, such as glomerulonephritis, vasculitis, splenomegaly, and hypergammaglobulinemia, located on multiple chromosomes.
- The study highlights specific QTLs labeled Scg and Sxb, focusing on the distinct role of Man-1 in regulating MPO-ANCA
Histone H3 is aberrantly phosphorylated in glutamine-repeat diseases.
Biochem Biophys Res Commun
February 2003
Article Synopsis
- Double-labeling immunohistochemistry using anti-ubiquitin and anti-phosphoserine antibodies, along with enzymatic dephosphorylation, shows that neuronal inclusions and nuclei in brain tissues of patients with glutamine-repeat diseases are improperly phosphorylated.
- The distribution of these phosphorylated nuclei in neurons relates directly to the disease pathology observed.
- Experiments isolating nuclear proteins from cells expressing the Huntington's disease gene reveal that increased aberrant phosphorylation of histone H3 is a common feature in the brains of those affected by these diseases, suggesting a shared pathological mechanism.