Identification of novel inhibitors for trigger factor (TF) of : an investigation.

Trigger factor, as a chaperone protein, is required for survival of Mycobacterium tuberculosis () in a stressed environment. This protein interacts with various partners in both the pre- and the post-translation processes, yet the crystal structures of the trigger factor remain unresolved. In this study, we developed a homology model of trigger factor to facilitate the discovery and design of inhibitors.

of Shows Chaperone-like Activity and Plays a Role in Stress Adaptation and Immunomodulation.

()-encoded factors protect it against host-generated stresses and support its survival in the hostile host environment. possesses two peptidyl-prolyl isomerases and a probable trigger factor encoded by which has an FKBP-like PPIase domain. PPIases are known to assist the folding of peptidyl-prolyl bonds and are involved in various cellular processes important for bacterial survival in host-generated stresses.

Macrophages in Microbial Pathogenesis: Commonalities of Defense Evasion Mechanisms.

Macrophages are key arsenals of the immune system against invaders. After compartmental isolation of a pathogen in phagosomes, the host immune response attempts to neutralize the pathogen. However, pathogens possess the ability to subvert these assaults and can also convert macrophages into their replicative niche.