Publications by authors named "Masuhiko Sano"
Background: Atypical peak alpha frequency (PAF) has been reported in children with autism spectrum disorder (ASD); however, the relationships between PAF, age, and autistic traits remain unclear. This study was conducted to investigate and compare the resting-state PAF of young children with ASD and their typically developing (TD) peers using magnetoencephalography (MEG).
Methods: Nineteen children with ASD and 24 TD children, aged 5-7 years, underwent MEG under resting-state conditions.
In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children.
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- The study investigates the effects of transcranial direct current stimulation (tDCS) on whole-brain networks related to the 40 Hz auditory steady state response (ASSR) in healthy adult males, utilizing graph theory for analysis.
- A randomized, sham-controlled, double-blinded crossover design was employed with 25 participants, comparing the effects of cathodal tDCS to a sham condition through magnetoencephalography measurements.
- Results indicated that tDCS significantly reduced the characteristic path length of brain networks, suggesting improved functional integration, especially in individuals with less integrated networks prior to stimulation.
Aim: The receptive language ability of individuals with autism spectrum disorder (ASD) seems to lag behind expressive language ability. Several autism-related genes may influence this developmental delay. Polymorphism of one such gene, namely, the contactin-associated protein-like 2 gene (CNTNAP2), affects receptive language in individuals with language delay.
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- The study examines the relationship between joint attention impairment and conceptual inference ability in 113 Japanese children with autism spectrum disorder (ASD).
- Researchers found a negative correlation, indicating that greater joint attention difficulties are linked to lower conceptual inference skills, with a Pearson's correlation coefficient of r (104) = -.285.
- The findings suggest that while joint attention impairment is connected to conceptual inference abilities, it does not correlate with expressive or receptive language skills.
Article Synopsis
- The study explores how resting-state functional brain networks differ between children with autism spectrum disorder (ASD) and typically developing (TD) children, using magnetoencephalography (MEG) data.
- It finds that children with ASD exhibit significantly lower "small-worldness" in the beta band, which is linked to higher social impairment scores as measured by the Social Responsiveness Scale.
- The research suggests that combining graph theory with MEG data could help identify biological markers for autism.
Article Synopsis
- Sub-threshold autistic traits are common in the general population and can lead to social adaptation issues for affected children.
- Researchers studied 67 children with autistic disorder and 57 typically developing children, assessing their intelligence and social reciprocity while investigating the impact of a specific genetic variation (rs2710102) in the CNTNAP2 gene.
- The study found that typically developing children carrying the A-allele of the rs2710102 polymorphism exhibited more sub-threshold autistic traits compared to those with the GG genotype, indicating the potential for using genetic markers to identify these traits in children.
Administering medical treatment or managing quarantine for a patient is particularly difficult when a patient harming others or causing self-harm because of severe depression, a manic state, or psychomotor agitation is also infected with COVID-19. Kanazawa University Hospital is the only facility able to manage such difficult cases occurring in Ishikawa prefecture, a local administrative area in Japan. The hospital has arranged a negative pressure apparatus in a psychiatric ward with two protection rooms.
View Article and Find Full Text PDFMany individuals with autism spectrum disorders have comorbid epilepsy. Even in the absence of observable seizures, interictal epileptiform discharges are common in individuals with autism spectrum disorders. However, how these interictal epileptiform discharges are related to autistic symptomatology remains unclear.
View Article and Find Full Text PDFIn children with autism spectrum disorder (ASD), joint attention is regarded as a predictor of language function, social skills, communication, adaptive function, and intelligence. However, existing information about the association between joint attention and intelligence is limited. Most such studies have examined children with low intelligence.
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