Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice.

In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized knockout mice. APOA1 is a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, and thus HDL; our recent work showed that deficiency of APOA1 increases bone marrow adiposity in mice. We found that deficient mice have greatly elevated adipocytes within their bone marrow compared to wild type counterparts.

High resolution computed tomography in fibrosing alveolitis associated with systemic sclerosis.

Objective: To investigate the use of high resolution computed tomography (HRCT) in diagnosis of patients with fibrosing alveolitis associated with systemic sclerosis (FA-SSc), and to determine predictors of disease progression.

Methods: We retrospectively studied 90 patients with SSc who had undergone an initial (Time 1) and followup (Time 2) clinical and HRCT evaluation, with a mean +/- SD interval of 5.14 +/- 2.

Asbestos-related pleuropulmonary diseases: evaluation with low-dose four-detector row spiral CT.

Purpose: To evaluate the depiction of lung and pleural asbestos-related lesions with low-dose four-detector row spiral computed tomography (CT).

Materials And Methods: Eighty-three male workers with a mean duration of occupational exposure to asbestos of 18 years underwent CT as part of a medicolegal investigation. CT examination included low-dose multi-detector row spiral CT of the entire thorax, with reconstruction of contiguous 5-mm-thick images, and thin-section CT, which served as the reference standard for the detection of pleural and parenchymal asbestos-related abnormalities.

Multi-detector row spiral CT angiography of the thoracic outlet: dose reduction with anatomically adapted online tube current modulation and preset dose savings.

Purpose: To evaluate image quality obtained with anatomically adapted online tube current modulation and preset minimum dose savings at multi-detector row spiral computed tomographic (CT) angiography of the thoracic outlet.

Materials And Methods: A total of 100 patients were evaluated for thoracic outlet arterial syndrome with spiral CT angiography (collimation, 4 x 1 mm; pitch, 1.75) both with and without dose reduction by means of anatomically adapted online tube current modulation and preset minimum dose savings.

Pulmonary embolus imaging with multislice CT.

Multiple data support the concept that single-slice and multislice CT have fundamentally modified the diagnostic approach of patients with suspected PE. Although the definitive role of spiral CT angiography in the diagnostic algorithm has yet to be determined, it is clear that CT angiography has numerous advantages compared with other diagnostic tests. Bearing in mind that an effective diagnostic strategy should be as flexible as possible to be applied in every clinical setting, the role of spiral CT angiography in the diagnostic algorithm has to be considered among several practical parameters, such as the experience of the attending physician, degree of severity of the patient's clinical condition, the availability of diagnostic equipment, and specific logistics.

Usefulness of coronal reformations in the diagnostic evaluation of infiltrative lung disease.

Purpose: To evaluate the diagnostic accuracy of coronal thin sections as an alternative to transverse high-resolution computed tomography (HRCT) scans in the diagnostic approach to infiltrative lung disease (ILD) with multislice computed tomography (MSCT).

Materials And Methods: Fifty consecutive patients referred for suspicion of ILD underwent MSCT (collimation: 4 mm x 1 mm; pitch: 1.75; scan time: 0.

Diagnosis of bronchiectasis with multislice spiral CT: accuracy of 3-mm-thick structured sections.

The aim of this study was to evaluate the accuracy of 3-mm-thick reconstructed sections in the diagnosis of bronchiectasis with multislice CT (MSCT). Forty consecutive patients suspected of bronchiectasis (23 females, 17 males; mean age 51 years) underwent MSCT of the entire thorax with a 4x1-mm collimation (120 kV, 0.5 s/rotation, 80 mAs/slice) and a pitch of 1.

Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data.

The purpose of this study was to investigate whether the severity of acute pulmonary embolism (PE) could be quantitatively assessed with spiral CT angiography (SCTA). Thirty-six consecutive patients without underlying cardiopulmonary disease and high clinical suspicion of PE underwent prospectively thin-collimation SCTA and echocardiography at the time of the initial diagnosis (T0) and after initial therapy (T1; mean interval of time T1-T2: 32 days). The CT severity score was based on the percentage of obstructed surface of each central and peripheral pulmonary arterial section using a 5-point scale (1: <25%; 2: 25-49%; 3: 50-74%; 4: 75-99%; 5: 100%).

[Multi-slice CT angiography of thoracic pathology: particularities and new indications].

This review consists in three main topics. At this time, technology does not allow for optimal functional and morphological evaluation of the cardiac chambers. However, a precise pretherapeutic map of the systemic supply of the lung can be non invasively obtained.

CT angiography of pulmonary embolism in patients with underlying respiratory disease: impact of multislice CT on image quality and negative predictive value.

Our objective was to evaluate the impact of multislice CT (MSCT) on image quality and diagnostic value of spiral CT angiograms. Over an 8-month period (January 2000 to August 2000), 134 consecutive patients, including 55 patients with underlying lung disease, underwent MSCT (group 1). Image quality and diagnostic results of CT angiograms were compared with those obtained in 125 consecutive patients, including 58 patients with underlying lung disease, evaluated with thin-collimation single slice CT (SSCT; group 2) over a similar period of time (January 1999 to August 1999).

Risk of pulmonary embolism after a negative spiral CT angiogram in patients with pulmonary disease: 1-year clinical follow-up study.

Purpose: To evaluate the effect of pulmonary disease on diagnostic utility of spiral computed tomographic (CT) angiography in clinical practice.

Materials And Methods: Three hundred thirty-four patients, including 215 patients with pulmonary disease (group 1) and 119 patients with no history of respiratory disorder (group 2), were referred for thin-collimation CT angiography of the pulmonary circulation as the first-line diagnostic test. Patients with negative angiograms who had not received anticoagulation therapy and who could be clinically followed up at 3 months, 6 months, and 1 year were considered in the final study groups (n = 185); 135 patients had lung disease (group 3), and 50 patients had no history of a respiratory disorder (group 4).

Longitudinal follow-up study of smoker's lung with thin-section CT in correlation with pulmonary function tests.

Purpose: To evaluate thin-section computed tomography (CT) in depicting longitudinal changes in the lung parenchyma.

Materials And Methods: One hundred eleven volunteers underwent sequential examination with thin-section CT and pulmonary function tests over a mean period of 5.5 years.

[Optimal screening tool for thoracic diseases: chest X ray or CT?].

There are good reasons to believe that screening of lung parenchymal diseases by CT is superior to chest radiographs. Nevertheless, conventional chest radiography often remains the first examination performed for evaluation of thoracic diseases and, irrespective of clinical indication, it plays an important role in screening procedures. The interpretation methodology of a chest radiograph in a screening condition is reviewed.

[Interpretation of thoracic radiographs re-examined and corrected with tomodensitometry].

To our knowledge, conventional chest radiography is not likely to become obsolete or disappear from the daily practice of medical imaging. As such, it is important to insure that chest radiographs are acquired using optimal technique. Evaluation of chest radiograph findings must be comprehensive and the art of reading chest radiographs must be well thought to physicians in training.

Peripheral pulmonary arteries: how far in the lung does multi-detector row spiral CT allow analysis?

Purpose: To analyze the influence of multi-detector row spiral computed tomography (CT) on identification of peripheral pulmonary arteries.

Materials And Methods: Peripheral pulmonary arteries were analyzed on optimally opacified contrast material-enhanced spiral CT angiograms in 30 patients devoid of pleuroparenchymal disease who underwent scanning with multi-detector row CT (collimation, 4 x 1 mm; pitch, 1.7-2.

Dose reduction in spiral CT angiography of thoracic outlet syndrome by anatomically adapted tube current modulation.

The aim of this study was to evaluate dose reduction in spiral CT angiography of the thoracic outlet by on-line tube-current control. Prospectively, 114 patients undergoing spiral CT angiography of the subclavian artery for thoracic outlet arterial syndromes were evaluated with and without tube-current modulation at the same session (scanning parameters for the two successive angiograms, one in the neutral position and one after the postural maneuver): 140 kV; 206 mA; scan time 0.75 s; collimation 3 mm; pitch = 1).

Thin-section CT finding in 250 volunteers: assessment of the relationship of CT findings with smoking history and pulmonary function test results.

Purpose: To evaluate the frequency and morphologic characteristics of air trapping in volunteers with various smoking habits.

Materials And Methods: Two hundred fifty volunteers (133 women, 117 men; mean age, 39 years), including 144 smokers, 47 ex-smokers, and 59 nonsmokers, prospectively underwent inspiratory and expiratory high-spatial-resolution computed tomography (CT) and pulmonary function tests (PFTs). The frequency and characteristics of air trapping were evaluated according to the population's smoking habits and PFT results.