Publications by authors named "Mastalerz L"
Background: Asthma is associated with a prothrombotic state. Plasma factor VIIa-antithrombin complex concentrations (FVIIa-AT) indirectly reflect the interaction of tissue factor (TF) with FVII. Since TF is a key initiator of coagulation in vivo, we hypothesized that FVIIa-AT are higher in asthma.
View Article and Find Full Text PDFBackground: Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.
View Article and Find Full Text PDFArticle Synopsis
- 15-oxo-eicosatetraenoic acid (15-oxo-ETE) is linked to arachidonic acid metabolism and was found to be overproduced in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD).
- A study involving patients with N-ERD, asthmatics who tolerate aspirin, and healthy controls measured levels of 15-oxo-ETE and leukotriene E (LTE) to evaluate their potential as diagnostic markers.
- Results showed that 15-oxo-ETE levels were significantly higher in N-ERD patients, leading to the development of the Aspirin Hypersensitivity Diagnostic Index (AHDI) which showed strong accuracy in
Aspirin therapy or biologics in AERD: Where do we go from here?
J Allergy Clin Immunol Pract
August 2024
Hospitalizations for sarcoidosis in Poland: impact of the COVID-19 pandemic.
Pol Arch Intern Med
January 2024
Article Synopsis
- Eosinophilic granulomatosis with polyangiitis (EGPA) is linked to a prothrombotic state, and this study aims to explore the role of coagulation factors FXI and FXII in this context.
- In a sample of 34 EGPA patients in remission, elevated levels of FXI were found to correlate with higher eosinophil counts and altered fibrin clot characteristics, indicating a connection between FXI levels and prothrombotic conditions.
- The findings suggest that targeting FXI could be beneficial for treating prothrombotic states in patients with EGPA, especially those exhibiting hypereosinophilia, making it a potential focus for future therapies.
Background: The cellular inflammatory pattern of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is heterogeneous. However, data on the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity are scanty. By examination of N-ERD patients based on clinical data and eicosanoid biomarkers we aimed to identify NEA endotypes potentially guiding clinical management.
View Article and Find Full Text PDFBackground: During the coronavirus disease 2019 (COVID-19) pandemic, it has become a pressing need to be able to diagnose aspirin hypersensitivity in patients with asthma without the need to use oral aspirin challenge (OAC) testing. OAC is time consuming and is associated with the risk of severe hypersensitive reactions. In this study, we sought to investigate whether machine learning (ML) based on some clinical and laboratory procedures performed during the pandemic might be used for discriminating between patients with aspirin hypersensitivity and those with aspirin-tolerant asthma.
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- Chronic exposure to particulate matter (PM) is linked to various health disorders, but how it affects the body on a molecular level is not entirely clear.
- The study found that human monocytes exposed to PM showed changes in specific microRNAs (miRNAs), with notable differences in miRNA patterns observed between winter and summer seasons.
- Certain miRNAs, particularly MiR-34c-5p and MiR-223-5p, were more active in winter and play roles in regulating pathways related to inflammation and stress responses, suggesting a connection between PM exposure and disease development.
Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E, prostaglandin E and prostaglandin D) and/or systemic (leukotriene E) production of arachidonic acid metabolites.
View Article and Find Full Text PDFIntroduction: Aspirin-exacerbated respiratory disease (AERD) is a phenotype of asthma characterized by eosinophilic inflammation in the airways, mast cell activation, cysteinyl leukotriene overproduction, and acute respiratory reactions on exposure to cyclooxygenase-1 inhibitors. Aspirin desensitization followed by daily high-dose aspirin therapy is a safe and effective treatment option for the majority of patients with AERD. However, there is still some percentage of the population who do not derive benefits from daily aspirin use.
View Article and Find Full Text PDFEicosanoids and Eosinophilic Inflammation of Airways in Stable COPD.
Int J Chron Obstruct Pulmon Dis
July 2021
Purpose: Lipid mediators, particularly eicosanoids, are associated with airway inflammation, especially with the eosinophilic influx. This study aimed to measure lipid mediators and cells in induced sputum, that could possibly reflect the inflammatory process in the bronchial tree of COPD subjects.
Patients And Methods: Eighty patients diagnosed with COPD and 37 healthy controls participated in the study.
Background: Aspirin desensitization followed by daily aspirin use is an effective treatment for aspirin-exacerbated respiratory disease (AERD).
Objective: To assess clinical features as well as genetic, immune, cytological and biochemical biomarkers that might predict a positive response to high-dose aspirin therapy in AERD.
Methods: We enrolled 34 AERD patients with severe asthma who underwent aspirin desensitization followed by 52-week aspirin treatment (650 mg/d).
Background: To date, there has been no reliable in vitro test to either diagnose or differentiate nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD). The aim of the present study was to develop and validate an artificial neural network (ANN) for the prediction of N-ERD in patients with asthma.
Methods: This study used a prospective database of patients with N-ERD (n = 121) and aspirin-tolerant (n = 82) who underwent aspirin challenge from May 2014 to May 2018.
Background: Induced sputum (IS) allows to measure mediators of asthmatic inflammation in bronchial secretions. NSAID-exacerbated respiratory disease (NERD) is recognized as a distinct asthma phenotype, usually with a severe course, eosinophilic airway inflammation, and increased production of pro-inflammatory eicosanoids. A more insightful analysis of NERD patients has shown this phenotype to be nonhomogeneous.
View Article and Find Full Text PDFBackground: Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood.
Objective: To investigate the effect of long-term AD on clinical, biochemical and radiological changes in N-ERD patients.
Background: Given increased risk of cardiovascular events in asthma we hypothesized that lipoprotein-associated phospholipase A (Lp-PLA), an enzyme involved in atherosclerosis, is associated with proinflammatory and prothrombotic blood alterations in this disease.
Methods: In 164 adult asthmatics (63 with severe asthma) we measured plasma Lp-PLA activity using the PLAC test. We determined its relations to inflammation and prothrombotic blood alterations.