pH-responsive stealth micelles composed of cholesterol-modified PLA as a nano-carrier for controlled drug release.

Present research is a preliminary report on the novel pH-responsive micelles based on an amphiphilic brush copolymer P(PEGMA)-b-P(DMAEMA-co-CPLAMA) used as the promising drug carrier. The copolymer was synthesized using cholesteryl poly(L-lactic acid) methacrylate (CPLAMA), poly(ethylene glycol) monomethyl ether methacrylate (PEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) with appropriate hydrophobic/hydrophilic ratios via atom transfer radical polymerization. The copolymer compositions were determined by H NMR.