Effectiveness of Simultaneous Combined Intervention for Enhancing Cognitive Function in Patients with Moderate Alzheimer's Disease.

Background: The evidence supporting the effectiveness of combined interventions in Alzheimer's disease (AD) patients remains inconclusive.

Objective: The aim of this study was to evaluate the mid- and long-term effectiveness of physical training, alone or combined with cognitive games, on cognitive performance in patients with moderate AD.

Methods: Seventy-nine AD patients (≈73% females, age of ≈70±1 years) were randomly divided into three groups: aerobic-based training (AT-group,  = 27), aerobic-based training plus cognitive games (ACT-group,  = 25), and a control group engaged in reading (CG,  = 26), two sessions per week.

Does acute aerobic exercise enhance selective attention, working memory, and problem-solving abilities in Alzheimer's patients? A sex-based comparative study.

Introduction: The present study aimed to evaluate the effect of acute aerobic exercise on certain cognitive functions known to be affected by Alzheimer's disease (AD), with a particular emphasis on sex differences.

Methods: A total of 53 patients, with a mean age of 70.54 ± 0.

Mid-Term and Long-Lasting Psycho-Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment.

This study investigated whether combining simultaneous physical and cognitive training yields superior cognitive outcomes compared with aerobic training alone in individuals with mild cognitive impairment (MCI) and whether these benefits persist after four weeks of detraining. Forty-four people with MCI (11 males and 33 females) aged 65 to 75 years were randomly assigned to an 8-week, twice-weekly program of either aerobic training (AT group, = 15), aerobic training combined with cognitive games (ACT group, = 15), or simply reading for controls (CG group, = 14). Selective attention (Stroop), problem-solving (Hanoi Tower), and working memory (Digit Span) tasks were used to assess cognitive performances at baseline, in the 4th (W4) and 8th weeks (W8) of training, and after 4 weeks of rest (W12).

Exploring stress response's role in executive function impairments among adults with early adverse childhood experiences.

Adverse childhood experiences (ACEs) are recognised as precursors to numerous physical and mental health challenges. However, research on their impact on inhibitory control and working memory, particularly among healthy young adults, remains limited. The role played by the stress response as a moderator in these effects is likewise underexplored.

Sleep and psychological factors are associated with meeting discharge criteria to return to sport following ACL reconstruction in athletes.

This study aimed to determine if sleep quality and psychological factors were associated with time to meet the discharge criteria to return to sport (RTS) following anterior cruciate ligament reconstruction (ACL-R) among athletes. A cohort-study design included 89 athletes following ACL-R. Each participant completed a battery of questionnaires at 6 different time points: within 3 days of injury occurrence and at post-surgery (1.

Acute Exercise and Cognitive Function in Alzheimer's Disease.

Background: Many studies have shown the impact of acute aerobic exercises (AAE) on cognition in healthy adults or at a pre-dementia stage. Few studies, however, have explored the positive effects of AAE in moderate Alzheimer's disease (ADM) patients.

Objective: Evaluating the effect of AAE on cognitive functions in ADM patients.

Inter-relationship between sleep quality, insomnia and sleep disorders in professional soccer players.

Objective: Insufficient sleep duration and quality has negative effects on athletic performance, injury susceptibility and athlete development. This study aimed to assess the sleep characteristics of professional Qatar Stars League (QSL) soccer players.

Methods: In a cross-sectional study, QSL players (n=111; 23.

Resilience after a neurological pathology: What impact on the cognitive abilities of patients with brain damage?

The aim of this study is to examine resilience in patients with traumatic brain injury and patients who suffered from stroke. As traumatic brain injury and stroke both have a recovery potential, we investigate cognitive recovery in this context. Given the involvement of resilience in physiological recovery and positive emotions in enhancing cognitive capacities, we hypothesised that resilience could be related to cognitive abilities and recovery following traumatic brain injury and stroke.

Traumatic brain injury and stroke: does recovery differ?

Background: Traumatic brain injury and stroke often lead to cognitive, neurological and psychological disorders, which can result in many difficulties. Despite the existence of various disorders, improving cognitive capacities may be possible for these two pathologies.

Objectives: The purpose of this study was to assess cognitive recovery in patients with traumatic brain injury and stroke and compare recovery between both groups.

Effect of Passive Hyperthermia on Working Memory Resources during Simple and Complex Cognitive Tasks.

The aim of this study was to verify the hypothesis that hyperthermia represents a cognitive load limiting available resources for executing concurrent cognitive tasks. Electroencephalographic activity (EEG: alpha and theta power) was obtained in 10 hyperthermic participants in HOT (50°C, 50% RH) conditions and in a normothermic state in CON (25°C, 50% RH) conditions in counterbalanced order. In each trial, EEG was measured over the frontal lobe prior to task engagement (PRE) in each condition and during simple (One Touch Stockings of Cambridge, OTS-4) and complex (OTS-6) cognitive tasks.

Conditions for exercising residents' voting rights in long-term care residences: a prospective multicenter study.

To assess voting conditions in long-term care settings, we conducted a multicenter survey after the 2009 European elections in France. A questionnaire about voting procedures and European elections was proposed in 146 out of 884 randomized facilities. Sixty-four percent of facilities answered the questionnaire.

Marked referential communicative behaviours, but no differentiation of the "knowledge state" of humans in untrained pet dogs versus 1-year-old infants.

The study examines whether untrained dogs and infants take their caregiver's visual experience into account when communicating with them. Fifteen adult dogs and 15 one-year-old infants were brought into play with their caregivers with one of their own toys. The caregiver gave the toy to the experimenter, who, in different conditions, placed it either above or under one of two containers, with both the infant or dog and the caregiver witnessing the positioning; in a third condition, the caregiver left the room before the toy was placed under one of the two containers and later returned.

Cognitive decrements do not follow neuromuscular alterations during passive heat exposure.

To investigate what triggers cognitive and neuromuscular alterations during passive heat exposure, eight volunteers performed simple (One Touch Stockings of Cambridge, OTS-4) and complex (OTS-6) cognitive tasks as well as neuromuscular testing (maximal isometric voluntary contractions of the thumb with electrical stimulation of the motor nerve and magnetic stimulation of the motor cortex). These tests were performed at the start (T1), after 1 h 30 min (T2), 3 h (T3) and 4 h 30 min (T4) of exposure in both hot (HOT) (Wet Bulb Globe Temperature [WBGT] = 38° ± 1.4°C) and neutral control (CON) (WBGT = 19° ± 0.

Alterations in cognitive performance during passive hyperthermia are task dependent.

The objectives of this study were to (1) assess the effect of passive heating upon attention and memory task performance, and (2) evaluate the effectiveness of the application of cold packs to the head on preserving these functions. Using a counter-balance design 16 subjects underwent three trials: a control (CON, 20°C, 40% rH), hot (HOT, 50°C, 50% rH) and hot with the head kept cool (HHC). In each condition, three attention tests and two memory tests were performed.

Reduced attention shift in response to auditory changes in subjects with tinnitus.

A current idea about the persistence of tinnitus is that fixation of this phantom auditory perception in the central auditory system may be influenced by attention to it. The present study investigated the mechanisms of involuntary attention and analysed performance in categorising sounds in tinnitus, simulated-tinnitus and control subjects. The sounds were presented in one ear and were preceded by presentation of frequent and deviant stimuli in the other ear.

Processing emotional information in Alzheimer's disease: effects on memory performance and neurophysiological correlates.

Background: There is some impairment of the ability of patients with Alzheimer's disease (AD) to perceive emotions, but this ability seems relatively preserved compared to the impairment of other cognitive domains. Few studies have focused on the link between emotional processing and other cognitive functions, such as memory or attention.

Objective: This study was designed to investigate whether the emotional content of a text can influence memory in patients affected by AD and whether this effect is related to attentional processes as measured by event-related potentials (ERP).

The effects of apomorphine on attentional processing in Parkinson's disease.

To ascertain whether variations in central dopaminergic transmission can differentially affect motor and cognitive processing, we studied the effects of apomorphine (APO) in 9 patients with Parkinson's disease (PD). The UPDRS motor scores and auditory event-related potentials (ERPs) obtained in the 'odd-ball' (OB) and in the 'covert orientation of attention' (COA) tasks were studied in the 'off' and in the 'on' state after an injection of APO. Although APO injection improved patients' motor status, it induced a significant increase in the latencies of the P2 and P3 ERP components in the OB.

Attentional deficits in Parkinson's disease: partial reversibility with naphtoxazine (SDZ NVI-085), a selective noradrenergic alpha 1 agonist.

Several authors have suggested that catecholamine depletion may affect attentional processes in human subjects and could be implicated in the frontal lobe syndrome that has been described in Parkinson's disease (PD). The present study reports the effects of a placebo and naphtoxazine (SDZ-NVI-085), a selective noradrenergic alpha 1 agonist. These substances were administered to nine parkinsonian patients who were assessed on measures of attention, including neuropsychological tests and evoked potentials.

Functional anatomy of human auditory attention studied with PET.

Positron emission tomography was used to investigate the functional anatomy of selective auditory attention in 17 right-handed male volunteers who submitted to different tasks: silent rest (REST) listening to frequent low- or rare high-pitched tones (LIS) delivered randomly to the right or the left ear, selective auditory attention where subjects had to attend to deviants in one ear, right (ATTR) or left (ATTL). Six subjects had the series REST, LIS, ATTR twice, eight subjects the series REST, LIS, ATTL, and the last three subjects the sereis REST, ATTR, ATTL. Event-related potentials were simultaneously recorded with PET and showed significant task and electrode site effects on the N100 amplitude.

Attention deficits in depression: an electrophysiological marker.

EVENT-RELATED POTENTIALS were recorded in young depressed subjects and compared with results from controls. Subjects were required to respond to targets (rare high-frequency sounds) presented to a designated ear, and to ignore targets presented to the non-designated ear as well as standards (frequent low-frequency sounds) presented to either ear. The results confirm those previously obtained with elderly depressed patients, showing the same general profile of electrophysiological and behavioural differences, and in particular a substantial reduction of the N200 amplitude in response to attended targets in depressed subjects.

Depression as a dynamical disease.

Mathematical models are helpful in the understanding of diseases through the use of dynamical indicators. A previous study has shown that brain activity can be characterized by a decrease of dynamical complexity in depressive subjects. The present paper confirms and extends these conclusions through the use of recent methodological advances: first episode and recurrent patients strongly differ in their dynamical response to therapeutic interventions.

Endogenous evoked potentials assessment in depression: a review.

Over the past 15 years, researchers have shown an increasing interest in using event-related potentials (ERPs) to study depression. These studies generally fall into four classes; 1), ERPs as a means of detecting depression; 2), ERPs as a tool for distinguishing subtypes of depression; 3), ERPs as a measure of pharmacological effectiveness; 4), ERPs as indicators of defective cognitive operations in depressed subjects. Results from these heterogeneous approaches are often inconsistent and disappointing.

Temporal localization of the response selection processing stage.

Response choice is one of the stages in the information processing model proposed by Sanders. It is influenced by stimulus-response (S-R) compatibility. Segmentation of the processing window in intervals between RT and peak latencies and between peak latencies, was used to test the assumption that the decisional processes would be concomitant with the N200 rather than the P300 component.

[Study of the organization of sensorimotor stages in man using delayed evoked potentials].

The main aim of this study was to test the relative organization of three of the stages of Sanders' 1990 information processing model: "features extraction", "response choice", and "motor adjustment". The variables influencing these stages: stimulus degradation, stimulus-response (SR) compatibility and preparatory period have been manipulated. Event related potentials (N100, N200, P300) and reaction time were recorded from ten healthy subjects, in a dichotic listening task.