Prolonged, low dose alpha-tocopherol therapy counteracts intercellular cell adhesion molecule-1 activation.

Background: Up-regulation of ICAM-1 at the vascular endothelial level is one of the most important promoters in the slow progression of a healthy vessel to an atherosclerotic one. The current study aimed to evaluate whether low dose of the antioxidant alpha-tocopherol affects the circulating soluble (s) ICAM-1 in healthy subjects.

Methods: Either alpha-tocopherol E (50 I.