Publications by authors named "Massimo Giroda"
Article Synopsis
- Breast cancer is the most common cancer diagnosed in pregnant women, particularly in early-stage cases during the first trimester.
- A study evaluated the safety and feasibility of breast-conserving surgery (BCS) followed by radiation therapy after delivery in 30 women diagnosed with early-stage breast cancer during this time, finding no immediate surgical complications or local recurrences for up to five years.
- Long-term follow-up (14-17 years) showed a small percentage of isolated local recurrences and metastases, with outcomes similar to those who underwent radical surgery, indicating that BCS is a viable option for early-stage breast cancer in pregnant patients.
The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of mitochondrial fission factor (MFF1 and MFF2), a molecule that controls mitochondrial size and shape, that is, mitochondrial dynamics, were overexpressed in patients with non-small cell lung cancer and formed homo- and heterodimeric complexes with the voltage-dependent anion channel-1 (VDAC1), a key regulator of mitochondrial outer membrane permeability. MFF inserted into the interior hole of the VDAC1 ring using Arg225, Arg236, and Gln241 as key contact sites.
View Article and Find Full Text PDFBreast cancer related lymphedema (BCRL) is frequent but strategies for an individualized risk assessment are lacking. We aimed to define whether tumor-specific pathological features, coupled with clinical and therapeutic data, could help identify patients at risk. Data from 368 patients with node-positive breast cancers were retrospectively collected, including 75 patients with BCRL (0.
View Article and Find Full Text PDFBackground: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms.
Methods: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultures (from five patient samples), three glioblastoma (GBM) tumor cell lines, and an intracranial model of glioblastoma in immunocompromised mice (n = 4-5 mice per group). Mechanisms of therapy-induced tumor reprogramming were investigated in a global metabolomics screening, analysis of mitochondrial bioenergetics and cell death, and modulation of protein phosphorylation.
Background: Breast reconstruction after mastectomy is currently considered an essential component in managing breast cancer patients, particularly those diagnosed at a young age. However, no studies have been published on the feasibility of immediate breast reconstruction in patients diagnosed and operated during the course of gestation.
Method: We retrospectively identified all breast cancer patients who were subjected to mastectomy and immediate breast reconstruction during pregnancy at the European Institute of Oncology between 2002 and 2012.
Aims And Background: Often neglected by large clinical trials, patients with uncommon breast malignancies have been rarely analyzed in large series.
Patients And Methods: Of 2,052 patients diagnosed with breast cancer and followed in our Institution from January 1985 to December 2009, we retrospectively collected data on those with uncommon histotypes, with the aim of investigating their presentation characteristics and treatment outcome.
Results: Rare histotypes were identified in 146 patients (7.