Publications by authors named "Massimiliano de Zambotti"

Nocturnal blood pressure (BP) monitoring offers valuable insights into various aspects of human wellbeing, particularly cardiovascular health. Despite recent advancements in medical technology, there remains a pressing need for a non-invasive, cuffless, and less burdensome method for overnight BP measurements. A range of machine learning models have been developed to estimate daytime BP using photoplethysmography (PPG), a readily available sensor embedded in modern wearable devices.

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Introduction: The use of psychotropic substances has negative short- and long-term health outcomes, including complex direct and indirect effects on sleep and sleep-cardiovascular function. Here, we investigate daily relationships between self-reported substance use and objective measures of sleep and sleep-related heart rate (HR) in community-dwelling young adults.

Methods: Fifty-five healthy young adults (M = 23.

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Study Objectives: Evaluate the performance of actigraphy-based open-source and proprietary sleep algorithms compared to polysomnography in children with suspected sleep disorders.

Methods: In a sleep clinic, 110 children (5-12 years, 54% female, 50% Black, 82% with sleep disorders) wore wrist-placed ActiGraph GT9X during overnight polysomnography. Actigraphy data were scored as sleep or wake using open-source GGIR and proprietary ActiLife software.

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Video games (VGs) are one of the most common forms of entertainment and their diffusion is constantly increasing. Although largely studied in the framework of their relationship with mental and physical health, the relationship of VGs with sleep are not yet fully understood. This review provides a systematic assessment of the studies that investigated the relationships between video gaming and sleep in adults.

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Article Synopsis
  • Most menstrual cycle studies have focused on small, lab-based samples of young women, limiting understanding of broader impacts across different ages and real-life conditions.
  • This study involved 116 healthy females, comprising young and midlife groups, using wearable tech to monitor finger temperature, heart rate, physical activity, and self-reported symptoms throughout the menstrual cycle.
  • Findings revealed that temperature fluctuated with the menstrual cycle phases, HR was lowest during menses for both groups, but sleep metrics remained stable regardless of cycle changes.
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Early adolescent drinking onset is linked to myriad negative consequences. Using the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) baseline to year 8 data, this study (1) leveraged best subsets selection and Cox Proportional Hazards regressions to identify the most robust predictors of adolescent first and regular drinking onset, and (2) examined the clinical utility of drinking onset in forecasting later binge drinking and withdrawal effects. Baseline predictors included youth psychodevelopmental characteristics, cognition, brain structure, family, peer, and neighborhood domains.

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Heavy alcohol drinking is a major, preventable problem that adversely impacts the physical and mental health of US young adults. Studies seeking drinking risk factors typically focus on young adults who enrolled in 4-year residential college programs (4YCP) even though most high school graduates join the workforce, military, or community colleges. We examined 106 of these understudied young adults (USYA) and 453 4YCPs from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) by longitudinally following their drinking patterns for 8 years from adolescence to young adulthood.

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The menstrual cycle is a loop involving the interplay of different organs and hormones, with the capacity to impact numerous physiological processes, including body temperature and heart rate, which in turn display menstrual rhythms. The advent of wearable devices that can continuously track physiological data opens the possibility of using these prolonged time series of skin temperature data to noninvasively detect the temperature variations that occur in ovulatory menstrual cycles. Here, we show that the menstrual skin temperature variation is better represented by a model of oscillation, the cosinor, than by a biphasic square wave model.

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Study Objectives: Evaluate wrist-placed accelerometry predicted heartrate compared to electrocardiogram (ECG) heartrate in children during sleep.

Methods: Children (n = 82, 61% male, 43.9% black) wore a wrist-placed Apple Watch Series 7 (AWS7) and ActiGraph GT9X during a polysomnogram.

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The purpose of this study was to evaluate the reliability and validity of the raw accelerometry output from research-grade and consumer wearable devices compared to accelerations produced by a mechanical shaker table. Raw accelerometry data from a total of 40 devices (i.e.

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Objective: Women's increasing workforce participation necessitates understanding unique life phases like menopause for enhanced workplace inclusivity. This research investigates the challenges and needs of peri-menopausal women in work settings, using the Job Demands-Resources model as a foundation.

Methods: A cross-sectional survey was administered to 351 working women aged 40 to 65 years in the United States.

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Wearable sleep trackers are increasingly used in applied psychology. Particularly, the recent boom in the fitness tracking industry has resulted in a number of relatively inexpensive consumer-oriented devices that further enlarge the potential applications of ambulatory sleep monitoring. While being largely positioned as wellness tools, wearable sleep trackers could be considered useful health devices supported by a growing number of independent peer-reviewed studies evaluating their accuracy.

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Wearable sleep-tracking technology is of growing use in the sleep and circadian fields, including for applications across other disciplines, inclusive of a variety of disease states. Patients increasingly present sleep data derived from their wearable devices to their providers and the ever-increasing availability of commercial devices and new-generation research/clinical tools has led to the wide adoption of wearables in research, which has become even more relevant given the discontinuation of the Philips Respironics Actiwatch. Standards for evaluating the performance of wearable sleep-tracking devices have been introduced and the available evidence suggests that consumer-grade devices exceed the performance of traditional actigraphy in assessing sleep as defined by polysomnogram.

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Article Synopsis
  • The study confirmed that structural covariance networks (SCN) from MRI data can identify heavy alcohol users and predict problematic drinking behavior in adolescents and young adults.
  • It utilized data from three independent studies with participants aged 14 to 37, comparing heavy drinkers (cases) to those with low or no alcohol use (controls).
  • Key findings showed that heavy drinkers had distinct brain network characteristics, indicating differences in brain region thickness and connectivity, which could help in understanding alcohol use disorders.
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Goal And Aims: To evaluate an automatic sleep scoring algorithm against manual polysomnography sleep scoring.

Focus Method/technology: Yet Another Spindle Algorithm automatic sleep staging algorithm.

Reference Method/technology: Manual sleep scoring.

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Introduction: This study examined the potential of a device agnostic approach for predicting physical activity from consumer wearable accelerometry compared with a research-grade accelerometry.

Methods: Seventy-five 5- to 12-year-olds (58% male, 63% White) participated in a 60-min protocol. Children wore wrist-placed consumer wearables (Apple Watch Series 7 and Garmin Vivoactive 4) and a research-grade device (ActiGraph GT9X) concurrently with an indirect calorimeter (COSMED K5).

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Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited.

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Goal And Aims: Evaluate the performance of a sleep scoring algorithm applied to raw accelerometry data collected from research-grade and consumer wearable actigraphy devices against polysomnography.

Focus Method/technology: Automatic sleep/wake classification using the Sadeh algorithm applied to raw accelerometry data from ActiGraph GT9X Link, Apple Watch Series 7, and Garmin Vivoactive 4.

Reference Method/technology: Standard manual PSG sleep scoring.

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Study Objectives: Adolescence is characterized by significant brain development, accompanied by changes in sleep timing and architecture. It also is a period of profound psychosocial changes, including the initiation of alcohol use; however, it is unknown how alcohol use affects sleep architecture in the context of adolescent development. We tracked developmental changes in polysomnographic (PSG) and electroencephalographic (EEG) sleep measures and their relationship with emergent alcohol use in adolescents considering confounding effects (e.

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Importance: The use of consumer-grade wearable devices for collecting data for biomedical research may be associated with social determinants of health (SDoHs) linked to people's understanding of and willingness to join and remain engaged in remote health studies.

Objective: To examine whether demographic and socioeconomic indicators are associated with willingness to join a wearable device study and adherence to wearable data collection in children.

Design, Setting, And Participants: This cohort study used wearable device usage data collected from 10 414 participants (aged 11-13 years) at the year-2 follow-up (2018-2020) of the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, performed at 21 sites across the United States.

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Article Synopsis
  • The study evaluated how the COVID-19 pandemic influenced sleep habits and recreational screen time among adolescents, revealing a significant increase in screen time and changes in sleep patterns.
  • Using data from 5,027 participants in the Adolescent Brain Cognitive Development (ABCD) Study, researchers found that screen time rose steeply during the pandemic, leading to shorter sleep durations and later bedtimes.
  • The results emphasize that while screen activities can help maintain social connections during challenging times, excessive use can negatively impact sleep quality, indicating a need for healthier screen time habits.
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Study Objectives: We sought to elucidate the interaction between sleep and mood considering menstrual cycle phase (menses and non-menses portions of the cycle) in 72 healthy young women (18-33 years) with natural, regular menstrual cycles and without menstrual-associated disorders. This work fills a gap in literature of examining mood in context of sleep and menstrual cycle jointly, rather than individually.

Methods: Daily subjective measures of sleep and mood, and date of menses were remotely, digitally collected over a 2-month period.

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This cross-sectional study investigated objective-subjective sleep discrepancies and the physiological basis for morning perceptions of sleep, mood, and readiness, in adolescents. Data collected during a single in-laboratory polysomnographic assessment from 137 healthy adolescents (61 girls; age range: 12-21 years) in the United States National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study were analysed. Upon awakening, participants completed questionnaires assessing sleep quality, mood, and readiness.

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Introduction: Abnormal stress responses have been linked to the etiology of insomnia. We investigated the relationship between insomnia, stress, hypothalamic-pituitary-adrenal (HPA) axis activity, and autonomic nervous system (ANS) function in adolescence.

Methods: Forty-seven post-pubertal adolescents (16-20 years old, 28 female) with (N = 16; insomnia group) and without (N = 31; control group) DSM-5 insomnia symptoms were assessed for stress levels and stress reactivity and underwent a standardized stress protocol (Trier Social Stress Test (TSST)), after an overnight laboratory stay.

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