Publications by authors named "Massala M"
Exp Gerontol
October 2016
Article Synopsis
- - Werner's syndrome (WS) is a genetic disorder that leads to premature aging, primarily studied through WS fibroblasts, which exhibit faster aging due to specific cellular issues like telomere shortening and halted DNA replication.
- - Unlike WS fibroblasts, human dermal keratinocytes (skin cells) from WS patients can proliferate extensively (over 100 population doublings) while still maintaining mechanisms that regulate growth, indicating they don't show signs of premature senescence.
- - The study suggests that certain tissues, like the epidermis, remain unaffected by WS-related aging symptoms, supporting the idea that Werner's syndrome is a form of segmental progeroid syndrome, affecting some cell types differently than others.
