Publications by authors named "Masroor A Khan"

Article Synopsis
  • Bioluminescent high-throughput screening (HTS) assays using firefly, Renilla, and NanoLuc luciferases are essential tools in research and drug discovery, but can be affected by various metal ions present in biological and environmental samples.
  • A study screened 21 metal ions in three different HTS assays, quantifying their interference with luminescence signals and developing optimized buffer variants for better luciferase performance.
  • Findings showed that metal ions significantly impacted bioluminescence signals in a way that correlates with known metal ion-ligand affinities, indicating complex interactions that vary depending on the type of luciferase and assay conditions used.
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Luminescence has found wide application in biology, biotechnology and medicine. Particularly, fluorescent and bioluminescent probes allow visualization of molecular targets at the cellular level and even macromolecules or single small-molecule analytes. Among the most reliable tools for visualization of molecular targets are so-called responsive probes, which change the intensity and colour of the emitted signal after interaction with a molecular target.

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It is of interest to estimate the effects of foliar spray (ISA) on essential oil yield, chemical constituents, antioxidant, and antimicrobial activities of fennel (Foeniculum vulgare Mill).Fennel was treated with ISA solutions at 40 and 80 mg L-1 doses. Application of ISA significantly augmented antioxidant and antimicrobial activities in addition to essential oil yield and its principal elements in fennel.

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This work aims to evaluate the potential of nickel (Ni), an essential micronutrient, as an oxidative stress inducer along with associated morphological and biochemical responses in different varieties of fenugreek (Trigonella foenum-graecum L.), a chief economically cultivated crop of India. Varietal differences in crop performance upon exposure to 0, 20, 40, 60 and 80 mg Ni kg soil reflects that Ni applied at 20 mg Ni kg soil offers growth-promoting effects, improved photosynthesis attributes, carbonic and nitrate reductase activities more profound in PEB followed by AFg2, AFg1 and UM185 variety.

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End stage renal disease has a list of consequences, cardiovascular being the most common. Inefficient dialysis can cause significant deposition of calcium all over the body, including heart valves making heart function impaired. We illustrate a case of 38-year-old female with end stage renal disease on peritoneal dialysis.

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We report our experience with elective stenting of lesions only involving the origin and proximal common carotid arteries. In 37 patients (42 vessels), procedural success was 95% (40 of 42 vessels) with 2 minor strokes (4.70%) and no major strokes.

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This study was performed to determine the risk factors for restenosis after successful carotid stenting. Of 222 patients who underwent successful carotid stenting, 179 (81%) had a follow-up study (carotid ultrasound and/or angiogram). Restenosis rate was 6.

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Intracoronary stenting has been shown to improve acute and long-term clinical results compared with coronary angioplasty. However, clinical outcome after medium Palmaz biliary (PB) stent implantation in very large native coronary arteries (> 4 mm in diameter) is unknown. This study evaluated restenosis and long-term clinical outcome after PB stenting in large native coronary arteries.

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