Publications by authors named "Masoumeh Kiani Zadeh"

Article Synopsis
  • - FXIII-A deficiency is a rare bleeding disorder linked to serious complications like brain hemorrhages and miscarriages, with a higher prevalence of a milder form (heterozygous deficiency) found in up to 3.5% of the population.
  • - Individuals with severe FXIII-A deficiency require consistent preventative treatment, while heterozygous individuals, especially women, may only need treatment during specific bleeding events.
  • - Personalized treatment strategies based on individual patient factors (e.g., age, weight, and clinical situation) are essential for optimizing the effectiveness of therapy for FXIII deficiencies.
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Epigenetic alterations have been observed in many hematological malignancies, including acute myeloid leukemia (AML). Many of these alterations result from mutations in DNA methyl transferase (DNMT) enzymes, disabling them to methylate target genes in a proper way. In this case-control study, we investigated the association between R882H mutation in gene and gene methylation in patients with AML.

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DNA methylation is a key epigenetic mechanism that is dysregulated in leukemia and plays a significant role in leukemogenesis. Ten-eleven translocation 2 (TET2) is one of the most frequently mutated genes among the DNA methylation regulators in hematologic malignancies, indicating its tumor-suppressor function. In this study, we investigated the expression and methylation status of TET2 in patients with AML.

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Hereby, we aimed to investigate the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) and Vascular Endothelial Factor-C (VEGF-C) besides the methylation of PTGS2 in AML patients. VEGF-C and PTGS2 expression analysis were evaluated in newly diagnosed AML patients and healthy controls by quantitative Reverse Transcriptase PCR method. Also, PTGS2 methylation status was evaluated by Methylation-Sensitive High-Resolution Melting Curve Analysis (MS-HRM).

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