Blue light emitting graphene quantum dots/ Rhodamine B doped gold nanostars for ratiometric detection of methotrexate.

In this work, an innovative ratiometric sensing platform was developed for the determination of methotrexate (MTX), an antifolate drug, a chemotherapy agent, and an immune system suppressant based on blue emission graphene quantum dots/Rhodamine B doped gold nanostars (B-GQDs/Au NSt-RB). The developed sensor was a dual-emission fluorescent probe with two major emission peaks at 440 nm (B-GQDs) and 580 nm (Au NSt-RB) by exciting at 330 nm. Based on the inhibiting effect of MTX on the system's fluorescence density, the stable ratiometric fluorescent probe was used for the rapid determination of MTX in aquatic solutions and spiked human serum samples.

In vitro interaction of human Wharton's jelly mesenchymal stem cells with biomimetic 3D scaffold.

Study of cell-biomaterial interaction is a crucial aspect of bone tissue engineering to find a state-of-the-art functional substitute. In present study, the Wharton's jelly mesenchymal stem cells (hWJ-MSCs) behavior on three-dimensional biomimetic nano-hydroxyapatite/chitosan/gelatin (nHA/CS/Gel) scaffolds was investigated. The outcome was assessed by histological, biochemical and morphological tests.

The effects of sulfur mustard on expression of TGF-βs variants in lung epithelial cell line.

Sulfur mustard (SM) is a blister-forming agent and can cause damages in various momentous human organs. Previous studies have demonstrated that chemical and mechanical injuries of epithelial cells cause to give rise the secretion of TGF-β1 and TGF-β2. These cytokines play a key role in respiratory remodeling due to SM.

Preparation and evaluation of novel nano-bioglass/gelatin conduit for peripheral nerve regeneration.

Peripheral nerves are exposed to physical injuries usually caused by trauma that may lead to a significant loss of sensory or motor functions and is considered as a serious health problem for societies today. This study was designed to develop a novel nano bioglass/gelatin conduit (BGGC) for the peripheral nerve regeneration. The bioglass nanoparticles were prepared by sol-gel technique and characterized using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction analysis.