A water-soluble polysaccharide from the roots of Eremurus spectabilis M. B. subsp. spectabilis: Extraction, purification and structural features.

A heteropolysaccharide ESP, was separated from a water extract of dried roots of Eremurus spectabilis by column chromatographies on DEAE-cellulose A52 and Sephadex G-100. Specific optical rotation, molecular mass and total carbohydrate content of ESP were -36.3°, 43.

On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress.

Experiencing psychosocial adversities in early life such as maternal separation (MS) increases the risk of psychiatric disorders. Immune-inflammatory responses have imperative roles in the pathophysiology of psychiatric disorders. MS relatively changes the composition of intestinal microbiota leading to an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and subsequently increases the corticosterone level.