Approach to the Synthesis of Unsymmetrical/Symmetrical Maleimides via Desulfitative Arylation at Different Temperatures.

New routes toward selective synthesis of both mono- and diaryl maleimides have been innovated. The mere requirement to this end is through the increase of temperature. The method works effectively for maleic anhydride and maleic acid as well.

C-H Activation under the Guise of Diels-Alder Reaction: Annulation toward the Synthesis of Benzo[e]isoindole-1,3-diones.

A new paradigm in the coupling of external alkenes with internal electron-deficient alkenes has been investigated in which an unprecedented annulation of vinylarenes on maleimides takes place. The reaction is carried out via a tandem in situ activation of both olefinic and aromatic C-H bonds of styrenes driving the reaction in a pseudo-Diels-Alder mode.

A Regioselective Metal-Free Construction of 3-Aroyl Coumarins by Csp2-H Functionalization.

A successive metal-free TBHP-mediated regioselective C-H functionalization of coumarins toward expedient synthesis of 3-aroyl coumarins is unveiled. The ongoing method conducted through the reaction of either coumarins or coumarin-3-carboxylic acids with aromatic aldehydes. The optimized reaction condition also worked well with benzyl alcohols and styrenes as surrogates for aldehydes, which bear latent carbonyl functionality.

A one-pot domino C-H, C-C activation in coumarins: a fast track to 2,3-diaryl benzo[b]furans.

An approach to synthesize 2,3-diaryl benzo[b]furans using coumarins and aryl bromides is developed. This state-of-the-art strategy capitalizes on a palladium-catalyzed one-pot decarbonylative diarylation of coumarins, paving the way to achieve biologically interesting 2,3-diaryl benzo[b]furans.