Isolation of two steroidal saponins with antileishmanial activity from L.

Background And Purpose: Alliums are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. (giant onion) which is named locally "Couria" in the Northeast of Iran, is grown widely in "Kouh-Sorkh" mountains in Khorasan province.

Experimental Approach: Phytochemical investigation of chloroform-methanol and aqueous extract of the plant resulted in the isolation and identification of two steroidal saponins, using comprehensive spectroscopic methods including 1D and 2D NMR and MS.

Effects of extracts and manna of on impaired cognitive function induced by scopolamine in mice.

Background And Purpose: Alzheimer's disease (AD) is a neurodegenerative disease specified by chronic and irreversible destruction of neurons. This study aimed to evaluate the effects of different extracts (aqueous, hydroalcoholic, hexane, and ethyl acetate) and manna of (EC) on impaired cognitive function induced by scopolamine in mice. EC is shown to have anti-cholinesterase-butyrylcholinesterase activities.

The Effectiveness of Extract Topical Formulation on the Cutaneous Leishmaniasis: A Randomized Controlled Clinical Trial.

Objective: Despite many attempts to treat leishmaniasis, new approaches are necessary to reduce the burden of disease. (Brazambel) has shown significant effects against parasites in some studies. This study aimed to investigate the effects of extract topical formulation on cutaneous leishmaniasis.

Ameliorative Effect of Aqueous and Hydroalcoholic Extracts of Boiss. on Murine Model of Experimental Colitis.

Background: Boiss. () is a flowering plant with several therapeutic properties including antiinflammatory, antioxidant, antimicrobial, and wound-healing activity. Regarding the side effects of drugs conventionally used for inflammatory bowel disease (IBD) treatment, we investigated the anticolitis properties of aqueous (SSAE) and hydroalcoholic (SSHE) extracts of on experimental colitis.

Cyclotide nanotubes as a novel potential Drug-Delivery System: Characterization and biocompatibility.

Cyclotides are a class of cyclic peptides that can be self-assembled. This study aimed to discover the properties of cyclotide nanotubes. We performed differential scanning calorimetric (DSC) to characterize their properties.

Isolation and identification of 6-methoxy parillin and coniferin from the bulbs of L.

Background And Purpose: Phytochemically, species are a rich source of important secondary metabolites especially steroidal saponin and sapogenins, flavonoids, and sulfur compounds. As a member of this genus, , which is locally known as "tareh kouhi", is an endemic plant of middle Asian countries.

Experimental Approach: Bulbs of were collected and air-dried in the shade.

Effects of on immune system mediated EAE model of multiple sclerosis.

Background: About 5 to 10 percent of the population in developed countries are affected by autoimmune diseases. One of the most important autoimmune disease with high prevalence rate is Multiple sclerosis in which there is currently no definitive cure for it, and most medications such as interferons are used only to limit the disease. The present study aims to investigate the effect of using fractions in an immune system mediated model of multiple sclerosis.

Morphological studies of self-assembled cyclotides extracted from as novel versatile platforms in biomedical applications.

Self-assembling peptides have attracted researchers' attention recently. They are classified as biomedical materials with unique properties formed in response to environmental conditions. Cyclotides are macrocyclic plant-derived peptides containing 28-37 amino acids that have the ability to self-assemble.

Fabrication and optimization of electrospun polymeric nanofibers loaded with 5-fluorouracil and rosemary extract.

Background: Topical 5-fluorouracil [5FU] is one of the mostly prescribed medications for different types of skin cancer; however, it is associated with drug resistance and adverse effects. Rosemary extract has promising dose-dependent antitumor effects, as well as a synergistic effect in combination with 5-fluorouracil besides sensitizing the 5-FU-resistant cells.

Objective: Polymeric nanofibers loaded with 5FU and rosemary extract were optimized to combine both ingredients in one controlled release drug delivery system, aiming to enhance the efficacy while retaining the adverse effects.

Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that causes chronic inflammation. Cyclotides are small plant proteins with a wide range of biological activity, making them a target for researchers to investigate. This study was conducted to investigate the possible effects of cyclotide-rich fractions from Viola odorata as an immunomodulatory agent in an experimental autoimmune encephalomyelitis (EAE) model of MS.

Isolation of dioscin-related steroidal saponin from the bulbs of L. with leishmanicidal activity.

are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. L. is a common edible vegetable in north regions of Iran, especially in Mazandaran province, where it is named "Alezi" and considerably used as a raw vegetable, to make dishes, and as a medicinal plant.

Isolation of Cinnamic Acid Derivatives from the Bulbs of .

Background: genus with 750 species is the most diverse genus in the Amaryllidaceae family. Historically, species have been used as medicinal plants, especially for prevention and treatment of cardiovascular diseases and considered as valuable sources of phytonutrients. Phytochemical investigation of , locally called "Anashq," which is an edible plant of the "Zagros" region (west of Iran) was conducted in the present study.