Conjugation of folic acid with poly (NVCL-co-PEGMA)-grafted chitosan as a new doxorubicin delivery system.

This paper aimed to investigate the synthesis of a novel drug delivery system (DDS) to target tumors and implement the controlled release of doxorubicin (DOX). Chitosan was modified with 3-mercaptopropyltrimethoxysilane and subjected to graft polymerization to implement grafting with the biocompatible thermosensitive copolymer of poly (NVCL-co-PEGMA). A folate receptor-targeting agent was obtained by attaching folic acid.