Publications by authors named "Masoud M Malekzadeh"
Troublesome Weight Loss: A Case Report of Large Gastric Phytobezoar.
Middle East J Dig Dis
July 2024
Gastric bezoar is a very rare clinical condition and hard to treat. Phytobezoars are one of the most common types of bezoars, which happens with the consumption of indigestible fibers. In this report, we presented an elderly man with gastric phytobezoar who presented with peptic ulcer and was treated successfully with proton pump inhibitor (PPI) and Coca-Cola.
View Article and Find Full Text PDFBackground: Tofacitinib, a selective inhibitor of JAK/STAT pathway, has recently become available in our region. Here, we examined the safety and efficacy of tofacitinib in active ulcerative colitis (UC).
Methods: In a prospective, non-randomized, placebo-free, 52-week clinical trial defined in two phases of induction and maintenance, adult patients with active UC and no response or loss of response to previous conventional treatments, or anti-TNF were recruited (IRCT20181217042020N2).
A 43-year-old man who was treated with interferon-beta for multiple sclerosis was presented with hypertension, headache, nausea/vomiting, blurred vision, and renal dysfunction. The treatment with drugs and dialysis relieved the symptoms. Despite plasmapheresis is known to cause improvement in renal function, no such improvement was seen in patient.
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- A study highlights the rising rates of inflammatory bowel disease (IBD) in Iran and introduces the Iranian Registry of Crohn's and Colitis (IRCC) as a response to this growing health concern.
- The IRCC is a comprehensive, multicenter registry involving over 100 gastroenterologists, utilizing a standardized questionnaire to gather critical patient data, which has shown reliable results in a pilot study of 553 patients.
- This registry is the first of its kind in the Middle East, aiming to enhance IBD patient care and provide valuable information for healthcare policy makers to better address IBD in Iran.
Background: High blood pressure is an important risk factor for all-cause mortality and cardiovascular mortality and morbidity among Iranians. We aimed to estimate its prevalence, correlates, and its rate of awareness, treatment, and control in South of Iran.
Methods: The Pars Cohort Study (PCS) was launched in a district of Fars province.
Non-high-density lipoprotein fractions are strongly associated with the presence of metabolic syndrome independent of obesity and diabetes: a population-based study among Iranian adults.
J Diabetes Metab Disord
June 2017
Background: Non-HDL-C as a valuable predictor of premature atherosclerosis, coronary events like first Myocardial infarction and cardiovascular mortality has a high accuracy of measurement both in fasting and non-fasting individuals. Metabolic syndrome (MetS) can promote the development of diabetes mellitus, endothelial dysfunction and atherosclerosis. A common pathway for cross linking of metabolic abnormalities and non-HDL-C has been suggested.
View Article and Find Full Text PDFQuality of clinical education for medical students has always been a concern in academic medicine. This concern has increased in today's time-squeeze while faculty members have to fulfill their complementary roles as a teacher, researcher, and practitioner. One of the strategies for program evaluation is obtaining trainees' feedbacks since they are the main customers of educational programs; however, there are debates about the efficacy of student feedback as a reliable source for reforms.
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- * Conducted with 77 sixth-year medical students at a pediatric center in Tehran, the study used the DREEM assessment tool to evaluate the educational experience and found critical areas needing improvement.
- * Key issues included students’ learning experiences and self-perceptions; proposed solutions involve structured training schedules, innovative teaching methods, and creating a supportive learning atmosphere.
Background: High blood pressure is the second most important risk factor of cardiovascular diseases (CVDs) in Iran. It is imperative to estimate the burden of CVDs that can be averted if high blood pressure is controlled at the population level. The aim of the current study was to estimate the avertable CVD mortality in the setting of Golestan Cohort Study (GCS).
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- Hereditary hemochromatosis (HH) is rare in Iran, and a family with severe juvenile hemochromatosis (JH) presents unique findings, with reported cases lacking HFE mutations.
- The study tracked siblings over three years, revealing two of them had clinical symptoms of JH, while the deceased brother had probable JH linked to findings of hyperpigmentation.
- Genomic analysis identified specific mutations in the HJV gene associated with JH and demonstrated the importance of molecular testing alongside MRI and liver stiffness monitoring for effective diagnosis and management of HH.
Article Synopsis
- A study in northeastern Iran examined the link between low-dose opium use and mortality from digestive disorders among 50,045 adults over an 8-year period.
- Of the participants, 17% reported using opium, with 474 deaths from digestive diseases, revealing a significant association between opium use and increased risk of death.
- The risk of dying from digestive diseases was dose-dependent, indicating that higher cumulative opium use corresponded to a greater chance of fatal outcomes, particularly from both cancerous and non-cancerous digestive issues.
Background: There is considerable variation in hypertension prevalence and awareness, and their correlates, across different geographic locations and ethnic groups. We performed this cross-sectional analysis on data from the Golestan Cohort Study (GCS).
Methods: Enrollment in this study occurred in 2004-2008, and included 50,045 healthy individuals from Golestan Province in northeastern Iran.