Publications by authors named "Masoud Gandomkar Ghalhar"
Background: Up-regulation of hsp90 gene expression occurs in numerous cancers such as lung cancer. D,L-lactic-co-glycolic acid-poly ethylene glycol-17-dimethylaminoethylamino-17-demethoxy geldanamycin (PLGA-PEG-17DMAG) complexes and free 17-DMAG may inhibit the expression. The purpose of this study was to examine whether nanocapsulating 17DMAG improves the anti cancer effect over free 17DMAG in the A549 lung cancer cell line.
View Article and Find Full Text PDFMesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which reside in bone marrow (BM), support homing of hematopoietic stem cells (HSCs) and self-renewal in the BM. These cells have the potential to differentiate into tissues of mesenchymal origin, such as fibroblasts, adipocytes, cardiomyocytes, and stromal cells. MSCs can express surface molecules like CD13, CD29, CD44, CD73, CD90, CD166, CXCL12 and toll-like receptors (TLRs).
View Article and Find Full Text PDFBackground: HSP90 may be overexpressed in cancer cells which are greatly dependent on Hsp90 function. Geldanamycin derivative 17 allylamino-17-demethoxygeldanamycin (17-AAG) inhibits the function and expression of HSP90. 17-AAG has poor water-solubility which is a potential problem for clinical practice.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the combined effects of daunorubicin (DNR) and the BH3-mimetic ABT-737 on acute myeloid leukemia (AML) cell lines HL60 and U937.
- The results showed that when DNR and ABT-737 were used together, the effective doses (IC50 values) of both drugs decreased significantly, indicating a synergistic effect that improved cell growth inhibition compared to using each drug alone.
- The findings suggest that ABT-737 enhances the cytotoxic effects of DNR by promoting apoptosis, which could help tackle chemotherapy resistance in leukemia patients.