Benchmark dose determining airborne crystalline silica particles based on A549 lung-cell line survival in an in vitro study.

Crystalline silica has emerged as a prominent occupational toxicant over extended periods, leading to the development of lung disease and cancer. The objective of this investigation is to establish a benchmark dose (BMD) for crystalline silica micro and nanoparticles based on the dehydrogenase activity of the A549 lung-cell line. The impact of exposure to crystalline silica micro-particles (C-SiO MPs) and crystalline silica nanoparticles (C-SiO NPs) on A549 epithelial lung cells was examined for durations of 24 and 72 h to evaluate cell viability using the MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay.

Prediction of size-selective permitted daily exposures for mineral oil mist based on an in vitro study in different scenarios.

The incidence of DNA damage from exposure to specific types of metalworking fluids has been reported. In this research, size-selective permissible limits to prevent genotoxic damage in A549 cell lines exposed to two types of mineral oil were estimated for the first time using a benchmark dose approach and extrapolated to workers. The comet assay was performed based on Olive and Banath protocol to determine DNA damage.

Application of a novel exposure limit approach for co-exposure of ‎chemicals: a field study by in-vitro design.

This study has suggested an occupational exposure limit (OEL) based on the co-exposure approach in an iron-foundry industry. Respirable dust was collected in an iron casting industry using the NIOSH 0600 method. The DNA damage was obtained by comet assay.

Health risk assessment of inhalation exposure to dry fogging of hydrogen peroxide in a dental clinic during the COVID-19 pandemic.

After the outbreak of COVID-19, many dental clinics use dry fogging of hydrogen peroxide (HO) to disinfect the air and surfaces. Inhalation of highly concentrated solutions of HO may cause severe respiratory problems. This study aimed to estimate the health risk assessments of inhalation exposure to dry fogging of HO in a dental clinic.