Intra-stromal injection of honey-treated keratocytes as a cell-based therapy for experimental corneal laceration.

Objectives: This study aimed to investigate the potential of honey-supplemented medium (HSM) for expanding corneal keratocytes and its transplantation in a model of corneal laceration.

Methods: Keratocytes were cultured in 1 % HSM- or 10 % fetal bovine serum (FBS)-supplemented medium for 24 h. The effect of HSM on keratocyte proliferation was evaluated using the MTT assay.

Autologous Activated Omental versus Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells in Corneal Alkaline Injury: An Experimental Study.

Purpose: To compare the effects of two types of mesenchymal stem cells (MSCs), activated omental cells (AOCs), and adipose tissue-derived stem cells (ADSCs) in the healing process of animal model of ocular surface alkali injury.

Methods: An alkaline burn was induced on the ocular surfaces of eighteen rats divided randomly into three groups. The first and second groups received subconjunctival AOCs and ADSCs, respectively.

Five Years Pathological Evaluation of Corneal Regrafts: A Study from Southern Iran.

Purpose: Corneal regrafts sometimes needed to restore the transparency after graft failure. The aim of the study is five years epidemiologic and histopathological evaluation of corneal regrafts.

Methods: In this cross-sectional study, all corneal regrafts during 5 years (2012-2016) were assessed in the Khalili Ophthalmology Center at Shiraz city.

Non-medial infectious orbital cellulitis: etiology, causative organisms, radiologic findings, management and complications.

Background: Orbital cellulitis is an ophthalmic emergency, which is associated with vision-threatening adverse effects. The purpose of this study is investigating etiology, radiologic findings, management and complications of patients with non-medial orbital cellulitis.

Method: A retrospective medical record and radiologic file review of patients with infectious orbital cellulitis was performed to detect all patients with non-medial orbital cellulitis who referred to Khalili hospital from 2016 to 2019.

Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model.

This study was conducted to compare the effect of nanofibrous polycaprolactone (PCL) and PCL/gelatin (PCL/Gel) on limbal epithelial stem cell (LESC) and its efficiency for transplantation in animal model. PCL and PCL/Gel with a mass ratio of 70:30 and 50:50 was fabricated by electrospinning method. Human LESCs were cultured on PCL and PCL/Gel scaffolds and the effect of each scaffold on LESC proliferation, attachment and corneal epithelial regeneration in an animal model was evaluated, considering ease of use of scaffold and final transparency of the cornea.

Caffeic Acid Alkyl Amide Derivatives Ameliorate Oxidative Stress and Modulate ERK1/2 and AKT Signaling Pathways in a Rat Model of Diabetic Retinopathy.

The purpose of this study was to examine the neuroprotective effects of caffeic acid hexyl (CAF6) and dodecyl (CAF12) amide derivatives on the early stage of retinopathy in streptozotocin-induced diabetic rats. Animals were divided in five groups (n=8/group); one group consisted of non-diabetic rats as control, while the other four were diabetic animals either non-treated or treated with CAF6, CAF12 or resveratrol intravitreally for four weeks. Retinal superoxide dismutase (SOD) activity and 8-iso-prostaglandin F (iPF ) levels were evaluated by an ELISA assay.

Expression of interleukin-6 in ocular surface squamous neoplasia.

Purpose: Interleukin-6 (IL-6) is an important cytokine in the cascade of inflammation and cancer progression. The aim of this study was to identify IL-6 expression in ocular surface squamous neoplasia (OSSN) in comparison with non-neoplastic conjunctival tissue.

Methods: Twenty paraffin-embedded tissue sections of conjunctiva from patients with OSSN including conjunctival intraepithelial neoplasia (CIN) in all grades of severity and squamous cell carcinoma (SCC) were assessed by immunohistochemistry staining for IL-6.

Choroidal changes after intravitreal injection of interferon alpha-2b.

Unlabelled: Intravitreal injection of interferon alpha-2b (IFN-α2b) is used to treat uveitis but its effect on the choroid is unknown. We histologically evaluated the choroidal changes after intravitreal injection of IFN-α2b. We compared histological samples of IFN-α2b-injected eyes to eyes with lipopolysaccharide (LPS)-induced uveitis and eyes injected with balanced salt solution (BSS) as controls.

Intra-vitreal injection of methotrexate in experimental endotoxin-induced uveitis in rabbit.

Uveitis is a major cause of vision loss. Methotrexate (MTX) has been widely used in uveitis due to its relatively safe profile. The purpose of this study was to evaluate the effects of two different dosages of MTX via intra-vitreal administration for treatment of endotoxin induced uveitis (EIU) in an experimental model.

Evaluation of intravitreal injection of pentoxifylline in experimental endotoxin-induced uveitis in rabbits.

The objective of the present study was to investigate the clinical and histopathological effects of intravitreal injection of pentoxifylline (PTX) the management of an experimental model of uveitis. Fifty-two rabbits were divided randomly into six intravitreal treated groups as below: 1) Balanced salt solution (BSS), 2) lipopolysaccharide endotoxin (LPS) + BSS, 3) LPS + PTX 100 μg, 4) LPS + PTX 500 μg, 5) BSS + PTX 100 μg and 6) BSS + PTX 500 μg. Inflammation was evaluated by clinical examinations using slit lamp on days 1, 3, 5 and 7 post injections and histopathological examinations were also performed at the end of the study.

Congenital Orbital Rhabdomyosarcoma.

Rhabdomyosarcoma (RMS) is the most common malignant tumor of the orbit in children, but it is rarely present at birth. We report a large congenital orbital RMS with intracranial extension in a newborn baby. A newborn baby girl was referred to our hospital due to severe right-eye exophthalmia.

Effect of Intraperitoneal Injection of Saffron on the Treatment of Experimental Endotoxin Induced Uveitis in the Rabbit.

Introduction: Saffron with scientific name of "" from the family "Iridaceae" is a plant without stem and root. Antioxidative and immunomodulatory effects of saffron has been demonstrated in different studies.

Aim: To assess the effects of saffron in the treatment on Lipopolysaccharide (LPS) induced uveitis in the rabbit.

Optic nerve glioma with complete intraocular extension.

Purpose: To present a rare presentation of optic nerve glioma (ONG) with total intraocular extension.

Methods: A 44-year-old man with a history of loss of vision since childhood and recent development of progressive disfiguring proptosis was referred.

Results: The vision in the affected eye was no light perception, and a proptosis of about 2-3 mm was present.

Omental transposition in treatment of severe ocular surface alkaline burn: an experimental study.

Since alkaline substances can rapidly penetrate into the cornea and subsequently damage limbal stem cells, another source of stem cells may be necessary to reconstruct the ocular surface. Omentum has some such characteristics like ability to regenerate tissue as well as anti-inflammatory capacity. Presence of adult stem cells and pluripotent embryonic cell markers make it suitable in wound healing; therefore, it seems reasonable to evaluate whether omentum can be helpful to restoration of ocular surface in severe alkaline burn.

Expression of maspin and ezrin proteins in periocular Basal cell carcinoma.

Background. The aim of this study was to investigate maspin and ezrin expression in different subtypes of periocular basal cell carcinoma (BCC). Methods.

Morphologic changes of corneal epithelial flap: ethanol-mediated versus mechanical removal.

Purpose: To evaluate morphologic changes in human corneal epithelial flap removed mechanically or after ethanol application.

Method: Epithelial corneal flap was removed after ethanol application (20 eyes) or mechanically (19 eyes). Any changes were studied by transmission electron microscopy.

Effect of different treatment regimen with dexamethasone and acetylcysteine on corneal wound healing in rabbits.

Background: The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexamethasone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits.

Methods: Eighteen adult New Zealand white rabbits were divided into three groups of six each.

Intrasclera schwannoma.

Schwannomas located in the eye are extremely rare and mainly arise from ciliary nerves. Ocular schwannoma usually present in the choroid, ciliary body or rarely sclera as a benign solitary amelanotic lesions. A 41-year-old woman presented with a history of decreased vision in her right eye of 3 months duration.

Choroidal neovascular membranes express toll-like receptor 3.

Background: Recent evidence has suggested a role for toll-like receptor 3 (TLR3) in experimental models of age-related macular degeneration (AMD). To date, however, few data exist about TLR3 in human AMD. The purpose of this study was to investigate the expression of TLR3 in human choroidal neovascular (CNV) membranes.

Aspergillus endophthalmitis in orthotopic liver transplantation.

In this report, we describe a patient with drug-induced liver failure who developed endogenous endophthalmitis after liver transplantation. Our patient's clinical course was so fulminant that the eye was lost in less than 1 month, without any response to therapy. Recognition of this infection is important because many patients die of disseminated Aspergillus infection, which may be detected early with bedside funduscopic examination by an ophthalmologist.

Effect of intravitreal triamcinolone acetonide in the treatment of experimental Staphylococcus epidermidis endophthalmitis.

Purpose: To investigate the effect of intravitreal injection of triamcinolone acetonide (TA) in the treatment of experimental Staphylococcus epidermidis endophthalmitis.

Materials And Methods: Experimental endophthalmitis induced in one eye of 38 rabbits by intravitreal injection of Staphylococcus epidermidis. The infected rabbits were randomly divided into three groups.

Deep anterior lamellar keratoplasty with melles technique for granular corneal dystrophy.

Purpose: The purpose of this study was to evaluate the clinical results of deep anterior lamellar keratoplasty (DALK) using the Melles technique in granular corneal dystrophy.

Methods: Seven eyes from 5 patients who underwent DALK using Melles technique for granular corneal dystrophy were included in this study. The parameters evaluated included patients' demographics, preoperative and postoperative best spectacle-corrected visual acuities (BSCVAs), and timing and pattern of recurrence.

Super oblique tendon elongation with fascia lata.

Purpose: Superior oblique lengthening with a silicone retinal band is used to treat superior oblique overaction (SOOA); however, secondary infection, implant extrusion, orbital cellulitis, and adhesion may occur. We present a method of superior oblique tendon elongation in which autogenous fascia lata is used to decrease the likelihood of these complications.

Methods: Six patients (5 female, 1 male) aged 7-22 years (mean, 17 years) with 40-85(Delta) exotropia and SOOA (range, +2 to +4; mean, +3.