Publications by authors named "Masood Ziaee"
Background: Toxoplasma gondii (T. gondii) is the most successful obligate protozoan that can infect warm-blooded vertebrate hosts. Some researchers suggest that the presence of Toxoplasma cysts in the brain can lead to mental disorders.
View Article and Find Full Text PDFBackground And Objectives: Understanding the epidemiology of species among cancer patients is crucial for preventing invasive infections. This study aimed to identify species and assess risk factors among cancer patients receiving chemotherapy in Birjand, eastern Iran.
Materials And Methods: The samples were obtained from the oral cavity of 140 patients and the initial identification of species was carried out through fungal cultures.
Article Synopsis
- * A study in eastern Iran found that 58.2% of hemophilia patients had SENV, compared to 20% in healthy individuals, with the highest prevalence in type A and severe cases.
- * The results emphasize the need for ongoing monitoring of SENV in hemophilia patients due to its significant presence and potential health complications.
Objectives: Human Papillomavirus (HPV) is a leading cause of cervical cancer, yet existing social stigmas and unequal access to healthcare compromise its preventability through screening and vaccination. Understanding healthcare professionals' knowledge and perceptions of HPV is pivotal in enhancing the quality and effectiveness of preventive healthcare strategies. This article aims to explore and understand the relationship between healthcare workers' knowledge and stigma towards HPV.
View Article and Find Full Text PDFBackground: Co-infection with other microorganisms such as parasites in patients with COVID-19 can affect the clinical outcome and require prompt diagnosis and appropriate therapy.
Case Presentation: We present a case of an adult male with chest pain, dyspnea, cough, diplopia, and anorexia who was confirmed to have acute COVID-19 pneumonia. 2 weeks prior to admission, a hydatid lung cyst was identified on examination, but the patient refused surgery.
Objectives: This study aimed to assess the severity and related factors of symptomatic COVID-19 in end-stage renal disease (ESRD) patients from several centers in Eastern Iran.
Methods: In this retrospective cohort study, after obtaining ethical approval, 410 patients diagnosed with COVID-19 were included for analysis. Patients were categorized into two groups based on their dialysis status: the dialysis group (ESRD patients undergoing hemodialysis) and the non-dialysis group (those without chronic dialysis).
Article Synopsis
- The study investigates the role of ACE1 and ACE2 gene variations in affecting susceptibility and severity of COVID-19 in patients versus healthy controls.
- It finds that individuals with the DD genotype of the ACE1 gene are more likely to contract COVID-19, while those with the ID genotype have lower susceptibility.
- There was no significant difference in the gene variations for ACE2, suggesting ACE1 polymorphism may be a potential risk factor for COVID-19.
Article Synopsis
- Global real-time monitoring of SARS-CoV-2 variants is essential for controlling COVID-19, leading to the development of a Sanger-based platform for variant tracking in low-resource labs.
- The study utilized nested RT-PCR and Sanger sequencing on 1,028 samples, achieving high concordance with whole genome sequencing for mutation detection and lineage assignment.
- The new method is effective for tracking variants of concern like Delta and Alpha, making it a viable option for countries with limited resources to monitor SARS-CoV-2 variants efficiently.
Article Synopsis
- The study analyzed the genetic diversity of SARS-CoV-2 in Iran over one year, following two independent viral introductions during the early outbreak phase.
- Researchers sequenced 319 whole genomes between March 2020 and May 2021 to monitor the circulating viral lineages.
- Results showed that different SARS-CoV-2 clades dominated various waves of infection, with the Delta variant emerging as a crucial factor in the fifth wave, highlighting significant mutations in key lineages.
Article Synopsis
- The study investigates factors affecting hepatitis B virus (HBV) infection outcomes in a highly endemic area of Iran, focusing on gene expression related to immunity and viral activity.
- Among 58 subjects, significant differences were found in the expression of certain genes, notably T-bet and IL-28/or IFN-λ2, highlighting the immune response in individuals with inactive chronic hepatitis B (ICB).
- The findings suggest that immune pressure may lead to reduced HBV activity in ICB patients, as indicated by the lower expression of HBx and the protective role of CREB against inflammation in the liver.
Background: Sepsis is a significant cause of mortality worldwide. This study aimed to compare clinical and laboratory characteristics of sepsis in patients addicted to illicit drugs versus patients with no illicit drug addiction.
Methods: In this cross-sectional study, all patients hospitalized with sepsis diagnosis were recruited within six months from September to March 2019.
In order to accurately interpret the immune response to COVID-19, it is critical to know how long serum antibodies to COVID-2 persist. This study aimed to describe the serum IgG responses to SARS-CoV-2 in patients with mild, moderate, and severe COVID-19 infection in Birjand, South Khorasan province, Iran. The study was performed on individuals whose COVID-19 disease was confirmed by RT-PCR and recovered from the disease.
View Article and Find Full Text PDFSurvival Evaluation of Hospitalized COVID-19 Patients with Cox Frailty Approach.
Disaster Med Public Health Prep
August 2022
Introduction: The survival cox analysis is becoming more popular in time-to-event data analysis. When there are unobserved /unmeasured individual factors, then the results of this model may not be dependable. Hence, this study aimed to determine the factors associated with Covid-19 patients' survival time with considering frailty factor.
View Article and Find Full Text PDFArticle Synopsis
- Health care workers are at a high risk of contracting and spreading SARS-CoV-2, prompting a study to assess the presence of antibodies among them at a hospital in Iran.
- The study analyzed blood samples from 180 medical staff and found that 24.4% were seropositive for anti-SARS-CoV-2 IgG, with a higher prevalence in males and significant associations with occupation and exposure to infected family members.
- The findings highlight the ongoing challenge of COVID-19 transmission in healthcare settings, emphasizing the need for continued preventive measures to protect HCWs and reduce infection rates.
We describe a family cluster of L. major that became infected by traveling to an endemic focus of CL, which did not respond to intralesional meglumine antimonial treatment whilst two were hospitalized due to the progressive disease that responded to 4 weeks of oral ketoconazole. Parasite genotyping of the internal transcribed spacer 1 gene revealed the same infecting parasite strain in all family members and was the same strain in GenBank that caused mucosal L.
View Article and Find Full Text PDFBackground: The combination of sofosbuvir and daclatasvir has shown preliminary efficacy for hospitalized patients with COVID-19 in four open-label studies with small sample sizes. This larger trial aimed to assess if the addition of sofosbuvir/daclatasvir to standard care improved clinical outcomes in hospitalized patients with COVID-19.
Methods: This was a placebo-controlled, double-blind, randomized clinical trial in adults hospitalized with COVID-19 at 19 hospitals in Iran.
Article Synopsis
- - Pre-existing fatty liver is common among hospitalized COVID-19 patients, with a prevalence of 37.9%, significantly higher than the 9.02% in patients admitted before the pandemic
- - The study compared 1162 hospitalized COVID-19 patients with fatty liver to a control group, assessing factors like hospitalization length and lung involvement
- - Results showed that COVID-19 patients with fatty liver experienced longer hospital stays and more severe lung involvement than those without fatty liver, highlighting a concerning association between the two conditions.
Introduction: Imbalances of various electrolytes, including calcium, are associated with the prognosis of Covid disease. This study investigated the relationship between serum calcium and clinical outcomes in patients with COVID-19.
Method: This study is a systematic review and meta-analysis by searching PubMed, Scopus, web of sciences until August 2021 using the keywords COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID, coronavirus disease, SARS-COV-infection.
Background: The present study aimed to determine the prevalence of bone density reduction and its associated factors in hemophilia patients in South Khorasan Province in 2018.
Materials And Methods: This case-control study was conducted on all patients with hemophilia type A with medical records in Hemophilia center in South Khorasan province. A number of 57 eligible subjects who met the criteria were selected based on census method.
Erratum to: SD1000: High Sustained Viral Response Rate in 1361 Patients With Hepatitis C Genotypes 1, 2, 3, and 4 Using a Low-cost Fixed-dose Combination Tablet of Generic Sofosbuvir and Daclatasvir: A Multicenter Phase III Clinical Trial.
Clin Infect Dis
July 2021
The SARS-CoV-2 virus has been rapidly spreading globally since December 2019, triggering a pandemic, soon after its emergence. While Iran was among the first countries confronted with rapid spread of virus in February 2020, no real-time SARS-CoV-2 whole-genome tracking in early phase of outbreak was performed in the country. To address this issue, we provided 50 whole-genome sequences of viral isolates ascertained from different geographical locations in Iran during March-July 2020.
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- The study focused on the prevalence and risk factors of HTLV-1 and blood-borne viral infections in Birjand, Iran, near the Afghan border.
- The sero-prevalence of HTLV-1 was found to be low at 0.3%, with most other viruses displaying similarly low prevalence rates.
- Hospitalization history was the main risk factor linked to HTLV-1 infection, and the study highlighted the need for increased awareness and education on blood-borne virus health risks to prevent future cases.
Toxoplasma gondii, the etiological agent of toxoplasmosis, can cause serious public health problems. Although Toxoplasma gondii tends more to neurotropic and ocular organs, some existing evidence suggest that this disease might induce serious pathological effects on liver. Hence, this study aimed to evaluate the relationship between chronic liver diseases and toxoplasmosis.
View Article and Find Full Text PDFBackground: Patients with chronic kidney failure and those undergoing chronic hemodialysis (CHD) treatment are at high risk of infection with hepatitis C virus (HCV). The incidence of occult HCV infection (OCI) in CHD remains controversial and the real burden of HCV in this population may be affected by the rate of OCI. This study evaluates the molecular assessment of OCI in CHD in an Iranian population.
View Article and Find Full Text PDFBackground: Gum bleeding in the absence of trauma or injury in adults with haemophilia is often reported. So hemophilic patients require special care and attention in various dentistry practices. The purpose of this study was to evaluate the gingival health status in patients with hemophilia in Birjand in 2018-2019.
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