Publications by authors named "Mason C Cleveland"
Article Synopsis
- Advances in large language models (LLMs) have led to numerous commercial and open-source models, but there has been no real-world comparison of OpenAI's GPT-4 against these models for extracting information from radiology reports.
- The study aimed to compare GPT-4 with several leading open-source LLMs in extracting relevant findings from chest radiograph reports using datasets from the ImaGenome and Massachusetts General Hospital.
- Results showed that GPT-4 slightly outperformed the best open-source model, Llama 2-70B, in terms of accuracy scores, with both showing strong performance in extracting findings from the reports.
Article Synopsis
- * Through advanced imaging techniques, researchers assessed the relationship between the vascular structure of the tumors and the treatment response, revealing that tumors responding to the drug had a more balanced blood vessel composition compared to resistant ones.
- * The findings suggest that understanding the vascular architecture could enhance our knowledge of how immune therapies work in the brain, potentially guiding future treatment strategies.
Article Synopsis
- Tumor angiogenesis often leads to abnormal blood vessel development, which is linked to treatment resistance and immune suppression in cancers, specifically brain metastases.
- A study using perfusion MRI on 44 patients treated with the immune checkpoint inhibitor pembrolizumab revealed that responsive tumors had balanced vascular structures, promoting better blood flow and a supportive immune environment.
- In contrast, resistant tumors exhibited chaotic blood vessels and low immune cell presence, with early functional changes detectable through MRI that indicated resistance before conventional imaging could.
