Functional Recovery of Carbon Nanotube/Nafion Nanocomposite in Rat Model of Spinal Cord Injury.

Background: Acute spinal cord injury (ASCI) can lead to paraplegia or quadriplegia, the treatment of which has been a major problem. New therapeutic approaches in developing carbon nanotubes (CNT) functionalized with the Nafion nanocomposite, a sulfonated tetrafluoroethylene copolymer, have been shown to increase the length of selected neurites in vitro.

Objective: We hypothesized that the administration of the CNT/Nafion nanocomposite after experimental SCI will promote regeneration of axons into the lesion cavity and the functional recovery of the hind limbs in a rat model.

An extended-release formulation of desferrioxamine for subcutaneous administration.

Desferrioxamine mesylate (DFO) remains the first line iron chelating agent. Since it has a short half-life and poor absorption through the gastrointestinal tract, DFO must be administered parenterally, usually by daily subcutaneous infusion administered over 8-12 h. The objective of this paper was the development of multivesicular liposome (depofoam) for the extended-release of DFO and study of iron excretion efficiency compared to the free form of DFO.

In vivo measurement of noradrenaline in the locus coeruleus of rats during the formalin test: a microdialysis study.

The locus coeruleus is involved in the regulation of the sense of pain. To demonstrate the changes in noradrenaline level in the locus coeruleus during the formalin test, a microdialysis probe was implanted into the left locus coeruleus of rats. Formalin was subcutaneously injected into the plantar surface of the right hind paw and pain ratings were recorded.