[Antidepressant pharmacokinetics during pregnancy].

The influence of pregnancy state on the cytochrome P-450 dependent bioconversion and pharmacokinetics of antidepressants has been studied. Specific features of the bioconversion of some antidepressants are determined. Results of pharmacokinetic investigations based on the dynamics of antidepressant concentration in the blood plasma of pregnant women are considered.

[The position of individual nuclei of the midbrain of children and adolescents with respect to stereotaxic coordinates].

As demonstrate macromicroscopical and stereological investigations, performed on 147 brain preparations of children and adolescents, beginning from newborns up to 17 years of age, the substantia nigra and the nucleus ruber of the midbrain demonstrate flattened, spindle-like and spherical forms, respectively, which do not change with age. Their linear dimensions and stereotaxic coordinates increase with age from 1 to 3 mm. Individual anatomical variability of the nuclei in question is not connected with sex, side of the brain and form of the skull.

[Individual anatomic variability of particular thalamic nuclei in children and adolescents with respect to stereotaxic coordinates].

As demonstrate macro-microscopic and stereologic investigations performed in 120 preparations of children and adolescent brain, the anterior, medial and lateral nuclei in the thalamus have a complex geometric form which does not change with age. Their linear dimentions and stereotaxic coordinates increase somewhat. These changes are described by means of mathematical models as regression equations.

[Individual variability in the subthalamic region of children and adolescents in relation to stereotaxic coordinates].

Macromicroscopic and stereologic examination of 120 specimens of the brain of children and adolescents showed that the subthalamic nucleus, zona incerta and Forel's fields have a simple geometric shape which does not change with age. Their linear dimensions increase a little and the stereotaxis coordinates alter. These changes are described by mathematical models in the form of regression equations.

[Role of cellular organelles in the reproduction of the influenza virus].

Virus-cell interaction may result in changes of both cell population and the original properties of the persisting virus. The elucidation of infectious RNA localization is of undoubtful interest in the light of the investigation of the mechanism of chronic influenza infection. The studies were aimed at comparing chronic and acute infections on the model of influenza virus.