[Long-COVID, severe course, with congenital bronchiectasis, Williams-Campbell syndrome. Case report].

We present a clinical observation of an 18-year-old female patient with congenital bronchiectasis combined with congenital cystic degeneration of the upper lobes of both lungs, Williams-Campbell syndrome, long-COVID, severe course. The patient was treated in infectious disease department (three times), with subsequent transfer to pulmonology department of Kursk Regional Multi-Purpose Clinical Hospital from 31.01.

[Effect of Mycoplasma arthritidis and Rauscher leukosis virus on murine peritoneal macrophages in vitro and in vivo].

The interaction of M. arthritidis and Rauscher leukemia virus (RLV) with mouse peritoneal macrophages was studied. When added in vitro, M.

[Induction of the immunologic response in vitro].

Immunological response (primary and secondary) was induced in a suspension of mouse splenic cells on nutrient media containing embryonic calf serum or serum against the erythrocytes of an animal--the lymphoid cells donor. The in vitro immunological response was accompanied by a specific increase in a number of the hemolysin-forming and rosette-forming cells. The optimal for induction of the immunological response in vitro was a dose of 10(7) erythrocytes per 1 ml of the culture.

[Cytopathic effect of the tularemia microbe on a culture of peritoneal macrophages].

Morphological analysis of the process of interaction of tularemia microbe strains differing by virulence with macrophages demonstrated that all these strains produced a lethal effect on macrophages obtained from the animales sensitive to the infection. The macrophages obtained from the animals were but little sensitive to tularemia and were resistant to the action of the causative agent of this infection. The data obtained led to a supposition on the presence in the tularemia causative agent of a factor responsible for its lethal action on the macrophages.

[Effect of inhibitors of nucleic synthesis on induction of the secondary immunologic response in vitro].

The authors studied the influence of the DNA and RNA inhibitors on the formation of antibody-forming cell populations in induction of a secondary immunological response in vitro. Low concentrations of cytosine-arabinoside, the DNA synthesis inhibitor, increased the count of indirect hemolysin-forming and rosette-forming cells; its high concentrations depressed the secondary immunological response induction in the direct hemolysin-forming cell system more intensively than in the indirect cell system. Actinomycin D depressed the stimulation of secondary immunological response in vitro both in the systems of direct and indirect hemolysin-forming, and of rosette-forming cells.

[State of the kinin system in burn shock and early toxemia].

State of kinin system was studied in blood serum of patients with burns of II, III, IIIb and IV degrees during shock and early toxemia. Content or activity of main components of kinin system (kininogen, kallikreinogen, kallikrein, kininase I (carboxypeptidase N)) were repeatedly estimated at 4-6 hrs intervals; BAEE-esterase and antitryptic activities were also studied within 48-72 hrs after the trauma. At the same period plasminogen and plasmin were estimated in 8 patients.

[Genetic control of the capacity of Sh. flexneri to exert a lethal effect on macrophages. II. Mapping of the cyt-determinant on the Shigella chromosome].

Crossing experiments showed independence of the genetic determinants controlling the capacity of Sh. flexneri to synthesize the primary S-specific side chains (antigen 3,4) and to produce a lethal action on macrophages cultivated in vitro. Cytotoxicity was restored only in transmission to the R-strain of shigellae of the capacity to synthesize the antigenic factor 3,4 from the cyt+, but not from the cyt-- donor of Sh.

[The effect of neuraminidase of C. diphtheriae on the functional capacity of the peritoneal exudate cells of guinea pigs to diphtheria bacilli].

A study was made of the effect of neuraminidase preparation containing no diphtheria toxin admixtures and hyaluronidase on the phagocytic activity of macrophages. Neuraminidase produced a stimulating effect on the cells of the developing macrophage culture. The macrophages treated with the enzyme increased their capacity to digestion of nontoxigenic diphtheria bacilli.

[Study of the role of type-specific antigen in the process of Shigella flexneri interaction with epithelial cell and macrophage cultures].

Epithelial cells of the HEp-2 line infected in parallel by genetically connected strains of Sh. flexneri, differing in the capacity to synthesize the type antigen were studied morphologically. The type antigen proved to show no significant influence on the penetration of dysentery bacilli into the cell.

[The role of the ability of Sh. flexneri to synthesize pili of the common type in the development of dysenteric infections].

HEp-2 epithelial cells infected with isogenic Sh. flexneri strains characterized by capacity to synthesize common pili (confirmed by electron microscopy) were studied. It was shown that although pili promoted an earlier adhesion of shigellae to the cells, they were not very significant for the penetration and intracellular development of dysentery bacilli in the epithelium.

[Effect of monoamine oxidase inhibitors on the phagocytic activity of macrophages].

Preparations studied in this work with the properties of monoaminoxidase (MAO) inhibitors caused a reduction of the phagocytic activity of cells and degeneration of the cell culture. By the extent of the toxic action on the macrophage culture the preparations could be distributed in the following order: chloracizine, chlorpromazine, vetrazine, indopan; biogenic amine serotonin influenced the phagocytic activity of cells only in very high concentrations. Macrophage cultivation in a medium containing MAO inhibitors led to quantitative and qualitative changes in the acid phosphatase granules.