Publications by authors named "Mashrur Rahman"

Objective: This study investigates various risk factors associated with pedestrian crash occurrence and injury severity based on 78,497 reported pedestrian-involved crashes across Texas from 2010 through 2019.

Methods: Crashes are mapped to over 708,738 road segments, along with road design, land use, transit, hospital, rainfall, and other location features. Negative binomial models examine the association between pedestrian crash frequency and various contributing factors, and a heteroskedastic ordered probit model investigates the severity of injuries at the individual crash level.

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Objective: To evaluate the effects of physiological levels of mitochondrial-derived reactive oxygen species (ROS) on skeletal muscle autophagy, a proteolytic pathway designed to regulate contractile and myofilament homeostasis and to recycle long-lived proteins and damaged organelles.

Results: Basal levels of autophagy and autophagy triggered by 1.5 to 4 h of acute nutrient deprivation, rapamycin treatment, or leucine deprivation were measured in differentiated C2C12 myotubes using long-lived protein degradation assays, LC3B lipidation, autophagy-related gene expression, and electron microscopy.

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It has been recently reported that p53 activation can lead to the induction of PKR-eIF2alpha phosphorylation pathway. However, we demonstrate that PKR and eIF2alpha phosphorylation at serine 51 are not downstream of p53 in response to doxorubicin treatment suggesting that PKR is not a universal target of p53 as proposed.

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