Publications by authors named "Mashio Taniwaki"
Article Synopsis
- * Patient symptoms included fever, headache, and hearing loss, with tests revealing infection indicators and abnormal brain lesions confirmed through advanced imaging techniques.
- * Rapid pathological diagnosis, including immunohistochemistry and PCR, played a vital role in distinguishing the cryptococcoma from a potential malignant tumor, leading to successful antifungal treatment.
Article Synopsis
- - The study focuses on improving the diagnosis of primary central nervous system lymphoma (PCNSL) during surgery by using intraoperative rapid immunohistochemistry (IHC), along with cytology and flow cytometry (FCM) for quicker and more accurate treatment decisions.
- - In a trial involving 35 patients from April 2020 to January 2024, the addition of cytology and FCM to rapid IHC significantly sped up the time from surgery to chemotherapy initiation for PCNSL (1.6 days versus 7.3 days), demonstrating the benefits of this combined approach.
- - Final pathological diagnoses confirmed the consistency of intraoperative rapid IHC results, and the combined method resulted in changes in treatment strategy in certain
Article Synopsis
- Primary intramedullary spinal cord lymphoma (PISCL) is a rare condition that is challenging to diagnose early due to vague symptoms and imaging results, necessitating a biopsy for confirmation.
- A case study of a 70-year-old woman who exhibited symptoms like lower-limb paralysis and abnormal sensations revealed a spinal mass and high β2-microglobulin levels, pointing toward PISCL.
- The study emphasizes that in cases resistant to treatment, PISCL should be considered, and spinal cord biopsy should be performed if PET scans show increased FDG uptake and elevated β2-microglobulin in cerebrospinal fluid.
Background: Amide proton transfer (APT) imaging has been proposed as a technique to assess tumor metabolism. However, the relationship between APT imaging and other quantitative modalities including positron emission tomography (PET) has not been investigated in detail. This study aimed to evaluate the clinical usefulness of APT imaging in determining the metabolic status of malignant glioma and to compare findings with those from C-methionine (Met)-PET.
View Article and Find Full Text PDFRecurrent glioblastoma multiforme (GBM) is largely attributed to peritumoral infiltration of tumor cells. As higher CD44 expression in the tumor periphery correlates with higher risk of GBM invasion, the present study analyzed the relationship between CD44 expression and magnetic resonance imaging (MRI)-based invasiveness of GBM on a large scale. We also quantitatively evaluated GBM invasion using 5-aminolevulinic acid (5-ALA) spectroscopy to investigate the relationship between CD44 expression and tumor invasiveness as evaluated by intraoperative 5-ALA intensity.
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- This study examined the effectiveness and safety of perampanel (PER) as a prophylactic treatment to prevent early seizures in patients with brain tumors, including glioblastoma (GBM).
- A total of 45 patients received PER after tumor resection, with no early seizures reported and minimal side effects observed, such as somnolence and vertigo.
- The results indicated that PER was as effective and safe as levetiracetam (LEV) in preventing seizures, with no major complications or adverse reactions noted in either group.
Background: Intravascular large B-cell lymphoma (IVLBCL) is a rare entity among large B-cell non-Hodgkin lymphomas and is often difficult to diagnose. We report the case of a patient with IVLBCL who presented with central nervous system (CNS) symptoms alone, in which positron emission tomography (PET) enabled a rapid and accurate diagnosis.
Case Description: An 81-year-old woman was admitted to our hospital with a 3-month history of gradually progressive dementia and declining spontaneity.
Background: The role of surgery in primary central nervous system lymphoma (PCNSL) is to allow pathological diagnosis from tumor biopsy. However, PCNSL is often difficult to distinguish from other tumors, particularly glioblastoma multiforme (GBM). Quantitative evaluations to facilitate differentiation between PCNSL and GBM would be useful.
View Article and Find Full Text PDFBackground: Hemangioblastoma originates in the central nervous system (CNS), usually in the cerebellum, and sporadic cases in the supratentorial region are extremely rare. In addition, there have been no previous reports of cases showing hyperintensity on diffusion weighted image (DWI) on magnetic resonance imaging (MRI) and negative immunostaining for inhibin-alpha. Here, we report a rare case of sporadic supratentorial hemangioblastoma arising in the parasagittal region and suggest a useful indicator for the exact diagnosis and pitfalls for surgical procedures.
View Article and Find Full Text PDFIn the treatment of primary central nervous system lymphoma (PCNSL), intraoperative rapid pathological diagnosis can dramatically change the surgical strategy, and more accurate diagnostic methods are required. In April 2020, we adopted intraoperative rapid immunohistochemistry (IHC) in addition to conventional rapid intraoperative diagnosis based on morphological assessment, mainly for patients with PCNSL. Here, we investigate the usefulness and significance of intraoperative rapid IHC based on our initial experience.
View Article and Find Full Text PDFIntroduction And Importance: Generally, schwannoma increases the concentration of protein in cerebrospinal fluid (CSF) and causes normal-pressure hydrocephalus (NPH) due to absorption disorders of CSF. Cases of NPH caused by spinal schwannoma in the cauda equina are very rare. Here, we report a case of spinal schwannoma-related NPH in the cauda equina successfully treated by surgical resection alone.
View Article and Find Full Text PDFBackground: Currently, immunotherapy is indicated for patients with metastatic RCC or unresectable RCC, but there is no indication for immunotherapy in the neoadjuvant setting. We report a case in which the combined use of nivolumab and ipilimumab and sequential TKI therapy enabled surgical treatment.
Case Presentation: A 71-year-old female was diagnosed with a metastatic clear-cell renal cell carcinoma with a level IV tumor thrombus.
Article Synopsis
- Differentiating between tumor and normal pituitary tissue is crucial for safely removing pituitary adenomas during endoscopic endonasal transsphenoidal surgery (ETSS).
- A study involving 24 patients tested the effectiveness of indocyanine green (ICG) fluorescence endoscopy, which lights up tumor boundaries and vital structures during surgery.
- Results showed that ICG endoscopy allows for clear distinction between tumors and healthy tissue by measuring how long it takes for fluorescence to appear, leading to better surgical outcomes and preservation of hormone functions.