South Asian-Specific Deletion Carriers Display Hypercontraction and Impaired Diastolic Function Under Exercise Stress.

A 25-base pair (25bp) intronic deletion in the gene enriched in South Asians (SAs) is a risk allele for late-onset left ventricular (LV) dysfunction, hypertrophy, and heart failure (HF) with several forms of cardiomyopathy. However, the effect of this variant on exercise parameters has not been evaluated. As a pilot study, 10 asymptomatic SA carriers of the variant (52.

Genetic Modifiers of Hereditary Neuromuscular Disorders and Cardiomyopathy.

Novel genetic variants exist in patients with hereditary neuromuscular disorders (NMD), including muscular dystrophy. These patients also develop cardiac manifestations. However, the association between these gene variants and cardiac abnormalities is understudied.

Stent placement for long-segment total occlusion of an aberrant right subclavian artery: A 7-year follow-up.

An aberrant origin of the right subclavian artery arising as the most distal vessel from the aortic arch is an uncommon but clinically important anomaly. Its abnormal course may result in esophageal compression with dysphagia, or tracheal compression resulting in asthma or stridor, and can greatly complicate radial artery access for coronary angiography. When an aberrant right subclavian artery is obstructed by atherosclerotic plaque, it may produce symptoms of arm ischemia such as pain and weakness.

Reverse Takotsubo cardiomyopathy: a story of a critically ill man with transient cardiac dysfunction.

Reverse Takotsubo cardiomyopathy (TCM) is a recently described variant of classic TCM. In contrast to classic TCM, the regional wall motion abnormalities are localized in the basal segments. The condition can be triggered by acute stressful events, including acute medical illnesses.