Complex Disease Genes Identification Using a Heterogeneous Network Embedding Approach.

Finding the causal relation between a gene and a disease using experimental approaches is a time-consuming and expensive task. However, computational approaches are cost-efficient methods for identifying candidate genes. This article proposes a new heterogeneous biological network embedding approach, named NetEM, to identify disease-associated genes.

An information theoretic approach to link prediction in multiplex networks.

The entities of real-world networks are connected via different types of connections (i.e., layers).

Link prediction in real-world multiplex networks via layer reconstruction method.

Networks are invaluable tools to study real biological, social and technological complex systems in which connected elements form a purposeful phenomenon. A higher resolution image of these systems shows that the connection types do not confine to one but to a variety of types. Multiplex networks encode this complexity with a set of nodes which are connected in different layers via different types of links.

A Pathway Analysis Approach Using Petri Net.

Perturbation in the normal function of the cell signaling pathways often leads to diseases. One of the factors that help understand the mechanism of diseases is the precise identification and investigation of perturbed signaling pathways. Pathway analysis methods have been developed as their purpose is to identify perturbed signaling pathways in given conditions.

FoPA: identifying perturbed signaling pathways in clinical conditions using formal methods.

Background: Accurate identification of perturbed signaling pathways based on differentially expressed genes between sample groups is one of the key factors in the understanding of diseases and druggable targets. Most pathway analysis methods prioritize impacted signaling pathways by incorporating pathway topology using simple graph-based models. Despite their relative success, these models are limited in describing all types of dependencies and interactions that exist in biological pathways.

Performance evaluation measures for protein complex prediction.

Protein complexes play a dominant role in cellular organization and function. Prediction of protein complexes from the network of physical interactions between proteins (PPI networks) has thus become one of the important research areas. Recently, many computational approaches have been developed to identify these complexes.

Using data fusion for scoring reliability of protein-protein interactions.

Protein-protein interactions (PPIs) are important for understanding the cellular mechanisms of biological functions, but the reliability of PPIs extracted by high-throughput assays is known to be low. To address this, many current methods use multiple evidence from different sources of information to compute reliability scores for such PPIs. However, they often combine the evidence without taking into account the uncertainty of the evidence values, potential dependencies between the information sources used and missing values from some information sources.

C-element: a new clustering algorithm to find high quality functional modules in PPI networks.

Graph clustering algorithms are widely used in the analysis of biological networks. Extracting functional modules in protein-protein interaction (PPI) networks is one such use. Most clustering algorithms whose focuses are on finding functional modules try either to find a clique like sub networks or to grow clusters starting from vertices with high degrees as seeds.