Photo-assisted epitaxial growth from nanoparticles to enhance multi-materialization for advanced surface functionalization.

To meet the requirements of freeform objects, a wide range of highly designable resin-based materials has been created, highlighting the need for low-temperature ceramic deposition methods for surface functionalization. Photo-assisted chemical solution deposition (PCSD), an efficient technique for low-temperature ceramic growth, is used to fabricate thin films photochemical and photothermal effects. The hybrid-solution-incorporated PCSD (HS-PCSD), in which a hybrid-solution comprising metal-organic compounds and nanoparticles is used in PCSD, has attracted considerable interest as it enables deposition at reduced temperatures and accelerated rates.

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes.

Background: Acute lung injury (ALI) is caused by a variety of illnesses, including aspiration pneumonia and sepsis. The CCR4-NOT complex is a large multimeric protein complex that degrades mRNA through poly(A) tail shortening, whereas it also contributes to regulation of transcription and translation. Cnot3 is a scaffold component of the CCR4-NOT complex and is essential for the integrity of the complex; loss of Cnot3 leads to depletion of whole complex.

Age estimation using postmortem computed tomography-based Hounsfield unit values of the palate and mandibular condyle and the Eichner classification.

Age estimation is important in forensic investigations of unidentified human remains. This study assessed the correlation between age and Hounsfield unit (HU) values of the palate and mandibular condyle based on postmortem computed tomography (CT) and analyzed the influence of occlusal support in developing an age estimation method for Japanese individuals, including older adults. The sample consisted of a training dataset (357 cadavers) and a validation dataset (300 cadavers) that underwent postmortem CT.

Emergent Three-Dimensional Electric Dipole Sinewave in Bulk Perovskite Oxides.

The magnetic and electric dipoles of ferroics play a central role in their fascinating properties. In particular, topological configurations have shown promising potential for use in novel electromechanical and electronic devices. Magnetic configurations from simple collinear to complex topological are well-documented.

Pretreatment periodontitis is predictive of a poorer prognosis after esophagectomy for esophageal cancer.

Background: Poor oral health is an independent risk factor for upper-aerodigestive tract cancers, including esophageal cancer. Several studies have investigated short-term outcomes after esophagectomy and the impact of periodontal disease, but few have examined the impact of periodontal disease on long-term outcomes. The purpose of this study was to investigate the rate of periodontitis among esophagectomy patients and the prognostic value of periodontitis and its effect on prognosis after esophagectomy.

Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva.

Heterotopic ossification (HO) is a non-physiological bone formation where soft tissue progenitor cells differentiate into chondrogenic cells. In fibrodysplasia ossificans progressiva (FOP), a rare genetic disease characterized by progressive and systemic HO, the Activin A/mutated ACVR1/mTORC1 cascade induces HO in progenitors in muscle tissues. The relevant biological processes aberrantly regulated by activated mTORC1 remain unclear, however.

Synergistic effect of zoledronate and compressive force suppresses proliferation and differentiation of human gingival fibroblasts.

We investigated the effects of zoledronate (ZA) and compressive force, separately and in combination, on the proliferation and differentiation of human gingival fibroblasts (HGFs) to verify the mechanism underlying medication-related osteonecrosis of the jaw (MRONJ). The addition of 100 µM ZA markedly inhibited cell proliferation. Expression of type I collagen, fibroblast growth factor 2, and connective tissue growth factor genes, was decreased by ZA and compressive force.

Collagen X Is Dispensable for Hypertrophic Differentiation and Endochondral Ossification of Human iPSC-Derived Chondrocytes.

Collagen X is a non-fibril collagen produced by hypertrophic chondrocytes and was believed to associate with the calcification process of growth plate cartilage. The homozygous loss of gene in mice, however, demonstrated no remarkable effects on growth plate formation or skeletal development. To investigate the role of collagen X in human chondrocytes, we established human induced pluripotent stem cells (hiPSCs) with heterozygous ( ) or homozygous ( ) deletions of gene using the dual sgRNA CRISPR/Cas9 system.

A-Site Columnar-Ordered Perovskite CaZnVO as a Pauli-Paramagnetic Metal.

In this study, we successfully synthesized a novel A-site columnar-ordered perovskite CaZnVO. This compound features a square-planar-coordinated Zn disorder, which is the same characteristic as the centrosymmetric paraelectric CaMnTiO. Unlike CaMnTiO, which shows a centrosymmetric paraelectric-noncentrosymmetric ferroelectric transition, CaZnVO retains Pauli-paramagnetic metallicity arising from itinerant V d electrons and centrosymmetry down to 5 K.

Experimental and studies on the structural, magnetic, photocatalytic, and antibacterial properties of Cu-doped ZnO nanoparticles.

Copper-doped ZnO nanoparticles with a dopant concentration varying from 1-7 mol% were synthesized and their structural, magnetic, and photocatalytic properties were studied using XRD, TEM, SQUID magnetometry, EPR, UV-vis spectroscopy, and first-principles methods within the framework of density functional theory (DFT). Structural analysis indicated highly crystalline Cu-doped ZnO nanoparticles with a hexagonal wurtzite structure, irrespective of the dopant concentration. EDX and EPR studies indicated the incorporation of doped Cu ions in the host ZnO lattice.

3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes.

Although the formation of bone-like nodules is regarded as the differentiation process from stem cells to osteogenic cells, including osteoblasts and osteocytes, the precise biological events during nodule formation are unknown. Here we performed the osteogenic induction of human induced pluripotent stem cells using a three-dimensional (3D) culture system using type I collagen gel and a rapid induction method with retinoic acid. Confocal and time-lapse imaging revealed the osteogenic differentiation was initiated with vigorous focal proliferation followed by aggregation, from which cells invaded the gel.

Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study).

Introduction: In early-stage oral tongue squamous cell carcinoma (OTSCC), elective neck dissection (END) is recommended when occult lymph node metastasis is suspected; however, there is no unanimous consensus on the risks and benefits of END in such cases. The management of clinically node-negative (cN0) OTSCC remains controversial. This study, therefore, aimed to evaluate the efficacy of END and its impact on the quality of life (QoL) of patients with cN0 OTSCC.

Suppression of Pressure-Induced Phase Transitions in a Monoclinically Distorted LiNbO-Type CuNbO by Preference for a CuO Triangular Coordination Environment.

Pressure-induced phase transitions in a monoclinically distorted LiNbO-type CuNbO with triangularly coordinated Cu and octahedrally coordinated Nb were experimentally and computationally investigated. Phase transitions into GdFeO-type or NaIO-type structures generally observed in LiNbO-type compounds below 30 GPa were not detected in CuNbO even at the maximum experimental pressure, 32.4 GPa.

Two Distinct Cu(II)-V(IV) Superexchange Interactions with Similar Bond Angles in a Triangular "CuV" Fragment.

The strength and sign of superexchange interactions are often predicted on the basis of the bond angles between magnetic ions, but complications may arise in situations with a nontrivial arrangement of the magnetic orbitals. We report on a novel molecular tetramer compound [Cu(HO)dmbpy][VOF] (dmbpy = 4,4'-dimethyl-2,2'-bipyridyl) that is composed of triangular "CuV" fragments and displays a spin gap behavior. By combining first-principles calculations and electronic models, we reveal that superexchange Cu-V interactions carry drastically different coupling strengths along two Cu-F-V pathways with comparable bond angles in the triangular "CuV" fragment.

SrVFeO: A Vacancy-Ordered Fe-Based Perovskite Exhibiting Room-Temperature Magnetoresistance.

We report room-temperature (RT) magnetoresistance (MR) in a novel Fe-based perovskite, SrVFeO. This compound contains ordered oxygen vacancies in every fifth primitive perovskite (111) plane, leading to a layered structure consisting of triple-octahedral and double-tetrahedral layers. Along with the oxygen vacancies, the transition-metal ions are also ordered: the octahedral sites are occupied by 100% of Fe ions, while the tetrahedral sites are occupied by 25% of Fe ions and 75% of V ions.

V-V Dimerization and Magnetic State of Cobalt Ions in Ilmenite-Type CoVO.

The nature of chemical bonds determines the electronic and magnetic properties of compounds. A metal-metal bonding (V-V dimer) and its effect on the magnetism of ilmenite-type CoVO were studied. Polycrystalline CoVO samples were synthesized using a high-pressure synthesis method.

A forensic autopsy case: Sudden unexpected death due to cardiac inflammatory myofibroblastic tumor.

We report an autopsy case of a 25-year-old man with no medical history who died suddenly in an Internet cafe. He was found in cardiorespiratory arrest and did not respond to cardiopulmonary resuscitation. Traumatic lesions were not observed on his body.

Polarization Rotation at Morphotropic Phase Boundary in New Lead-Free NaBiVTiO Piezoceramics.

In this work, we show that polarization rotation enhances the piezoresponse in a high-performance lead-free piezoelectric material, NaBiVTiO, a solid solution between tetragonal NaBiVO and rhombohedral NaBiTiO, obtained by high-pressure synthesis. The system forms a pure perovskite structure with a favorable morphotropic phase boundary (MPB) located around = 0.90, which separates the tetragonal and rhombohedral phases.

Abscopal effect of radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma: A case report.

The Abscopal effect is a rare phenomenon whereby tumors outside of the irradiated field regress due to systemic antitumor effects of localized radiotherapy. In patients with oral mucosal melanoma, only one instance of the abscopal effect has been described in the English-language literature [1]. Herein, we describe an instance of the abscopal effect following whole-brain radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma.

Sequential Spin State Transition and Intermetallic Charge Transfer in PbCoO.

Spin state transitions and intermetallic charge transfers can essentially change material structural and physical properties while excluding external chemical doping. However, these two effects have rarely been found to occur sequentially in a specific material. In this article, we show the realization of these two phenomena in a perovskite oxide PbCoO with a simple ABO composition under high pressure.

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery.

Octacalcium phosphate and its collagen composite have been recognized as bone substitute materials possessing osteoconductivity and biodegradation properties. We evaluated the effectiveness of octacalcium phosphate and its collagen composite used for bone augmentation in major oral and maxillofacial surgeries in a clinical trial. Octacalcium phosphate and its collagen composite were used in cases of sinus floor elevation in 1- and 2-stage, socket preservation, cyst, and alveolar cleft procedures.