Background: This prospective, post-marketing observational study in Japanese patients aimed to evaluate the safety and effectiveness of daily afatinib use in general practice.
Methods: This non-interventional study (NCT02131259) enrolled treatment-naïve and pre-treated patients with inoperable/recurrent EGFR mutation-positive NSCLC, eligible for afatinib treatment as per the afatinib label in Japan. Patients received afatinib at the approved dose (20, 30, 40, or 50 mg/day; physician decision), and were observed following treatment initiation for 52 weeks or until premature discontinuation.
The photoluminescence of a series of Eu(3+) doped layered silicates (kanemite, octosilicate, magadiite and kenyaite) was examined; it was found that layer thickness affected the luminescence intensity, suggesting the possible effects of the spatial separation of Eu(3+) in the direction perpendicular to silicate sheets on the luminescence self-quenching.
View Article and Find Full Text PDFNihon Yakurigaku Zasshi
June 2009