Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis.

A 20-year-old man presented with pain and recurrent hemarthrosis in the right knee. Magnetic resonance imaging of the knee showed a lesion with homogeneous low signal intensity on T1-weighted images and a heterogeneous, low to high signal intensity on T2-weighted images. At arthroscopy, the mass was located between the posterior cruciate ligament and the posterior knee joint capsule.

The effect of bevacizumab on tumour growth of malignant fibrous histiocytoma in an animal model.

Background: Bevacizumab is a specific inhibitor of angiogenesis and a neutralising antibody against vascular endothelial growth factor (VEGF). The effect of bevacizumab was evaluated on malignant fibrous histiocytoma (MFH) in vivo using an animal model.

Materials And Methods: MFH cell line, NaraH, was implanted to athymic nude mice which were randomly divided into a treatment and a control group.

Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412.

Background: PKC412, formerly CGP41251, N-benzoylstaurosporine, was initially developed as a selective protein kinase C (PKC) inhibitor, and it preferentially inhibits conventional PKC family members. In this study, the expression of PKCa was examined in human osteosarcoma and MFH cell lines, and the inhibitory effect of PKC412 on the proliferation of the cell lines was evaluated.

Materials And Methods: Three human osteosarcoma cell lines (KTHOS, MG63 and KHOS) and four human MFH cell lines (TNMY1, GBS-1, Nara-F and Nara-H) were used.

Magnetic resonance imaging of medullary bone infarction in the early stage.

Medullary bone infarctions, which are believed to arise due to arterial obstructions in the bone, are usually asymptomatic and are noted incidentally in roentgenograms or bone scans performed for other reasons. We present two cases of acute bone infarctions that were found accidentally by magnetic resonance imaging (MRI). In both cases, conventional radiographs could not demonstrate any findings and the cases were clinically asymptomatic.

Imatinib mesylate inhibits tumorigenicity of malignant fibrous histiocytoma cells in vivo.

Background: Malignant fibrous histiocytoma (MFH) is one of the most diffuse and aggressive tumors among soft tissue sarcomas in adults, but still poorly characterized from the molecular viewpoint. MFH cell proliferation is inhibited selectively by imatinib mesylate, a tyrosine kinase inhibitor. The expressions of platelet-derived growth factor receptors (PDGFRs) and c-Kit have been previously examined in MFH cell lines and the inhibitory effect of imatinib mesylate on the MFH cell proliferation was tested.

Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors.

Background: Tumor angiogenesis and vascularization are essential requirements for the growth and metastasis of tumors. There is evidence that overexpression of the vascular endothelial growth factor (VEGF) is correlated with an adverse prognosis in some tumors. The expression of VEGF, its receptors and microvessel density (MVD) of bone and soft tissue tumors was evaluated.