Publications by authors named "Masatoshi Yoshikane"
Article Synopsis
- Proximal renal tubular dysfunction is common during diabetic ketoacidosis (DKA) in newly diagnosed type 1 diabetes, but previous studies have lacked comprehensive analysis of its multiple functions and have not explored distal tubular function.
- In a study involving patients with and without DKA, those with DKA showed significantly higher levels of urinary β2-microglobulin and lower blood pH and phosphorus reabsorption, indicating renal dysfunction.
- The findings suggest that DKA in type 1 diabetes may lead to multiple proximal tubular dysfunctions resembling transient Fanconi syndrome, while distal renal tubular acidosis is unlikely to be present.
Infection remains the primary cause of death in extremely-low-birth-weight infants (ELBWIs). Alpha 1 acid glycoprotein (α1AG), an acute-phase protein, has been shown to be elevated in sporadic cases of septic ELBWIs prior to abnormal clinical signs. To delineate the roles of inflammation, delivery, and feeding in postnatal α1AG changes in ELBWIs, 75 ELBWIs of 26.
View Article and Find Full Text PDFBackground: The immunosuppressant mizoribine (Miz) can reduce progression of childhood IgA nephropathy (IgAN). This study examined whether Miz affects CD163 M2-type macrophages which are associated with kidney fibrosis in childhood IgAN.
Methods: A retrospective cohort of 90 children with IgAN were divided into groups treated with prednisolone (PSL) alone (P group; n = 42) or PSL plus Miz (PM group; n = 48) for a 2-year period.