[An analysis of the relation between stress coping profile and job stress using structural equation modeling (SEM)].

Objectives: This study aimed to clarify what type of coping profile can reduce the stress reaction caused by job stress.

Methods: Using the Brief Job Stress Questionnaire and the Brief Scales for Coping Profile Questionnaire, 1,319 male workers in Japanese manufacturing companies were surveyed. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and Structural Equation Modeling (SEM) were used for the statistical analysis.

The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin.

The amino acid sequence His-Pro-Phe as N-terminal residues 6-8 of the natural renin substrate, angiotensinogen, is conserved among species. We investigated whether this His-Pro-Phe motif functions as the determinant of the substrate specificity of renin. Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.