Publications by authors named "Masatoshi Kaizuka"
Introduction: Esophageal achalasia is a typical esophageal motility disorder (EMD). Although viral infections have been hypothesized to play a role in the pathogenesis of esophageal achalasia, its etiology remains unclear. This study used esophageal muscle layer specimens collected during per-oral endoscopic myotomy (POEM) procedures to investigate the association between esophageal achalasia and esophagogastric junction outflow obstruction (EGJOO) and pattern recognition receptors.
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- TLR7 is crucial for the immune response to viral infections in cells like astrocytes and microglia, but its function in neurons is not fully understood yet.
- This research examined how resiquimod, a TLR7/8 activator, affects inflammatory chemokine production in SH-SY5Y human neuroblastoma cells, finding that TLR7 is always present in these cells.
- The study showed that resiquimod boosts CCL2 expression and activates NF-κB, suggesting it could have therapeutic potential for treating viral infections in the central nervous system by stimulating immune responses in neurons.
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- The study investigates the relationship between liver fibrosis and reactive oxygen species (ROS) levels produced by neutrophils, focusing on how this varies with age and sex in the general population.
- It involved 1,000 participants categorized into four groups based on sex and age, using various indices to assess liver fibrosis.
- Findings indicated positive correlations between liver fibrosis scores and basal ROS levels in younger participants, while in females, higher liver fibrosis scores were associated with lower stimulated ROS levels, suggesting that enhancing neutrophil function could help prevent liver-related diseases.
A novel treatment method for achalasia of the esophagus and related disorders is known as peroral endoscopic myotomy (POEM). This study aimed to calculate the resting energy expenditure (REE) and evaluated the degree of physical invasiveness based on metabolic changes during the perioperative period of POEM. Fifty-eight patients who underwent POEM were prospectively enrolled; REE, body weight (BW), and basal energy expenditure were measured on the day of POEM, postoperative day 1 (POD 1), and three days after POEM (POD 3).
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- * After matching participants based on various health factors, researchers found significant differences in gut microbiota diversity between those with and without liver fibrosis, but no notable differences in oral microbiota.
- * The results suggest that gut microbiota may play a more significant role in liver fibrosis than oral microbiota, although certain strains didn't independently influence liver fibrosis when adjusting for other health variables.
Esophageal endoscopic submucosal dissection (ESD) is considered to be more complex than gastric ESD. This study aimed to assess the physical invasiveness of esophageal ESD during perioperative periods by measuring resting energy expenditure (REE). The factors affecting REE that could be used to identify patients requiring perioperative management were also investigated.
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