Publications by authors named "Masatoshi Iwamoto"
Article Synopsis
- ClC chloride channels are crucial for maintaining cell volume, cytoplasmic ion composition, and regulating electrical activity, with new research suggesting they may function as H+-Cl- exchange transporters.
- Molecular dynamics simulations were conducted to better understand the mechanisms of these channels, particularly how they open and allow ions to pass through.
- The findings showed that H+ and Na+ ions both trigger channel opening, and Na+ leads to the formation of a unique string of Cl- and Na+ ions that facilitate ion movement into the cell.
Molecular dynamics analyses were performed to examine conformational changes in the C-domain of calmodulin and the N-domain of troponin C induced by binding of Ca(2+) ions. Analyses of conformational changes in calmodulin and troponin C indicated that the shortening of the distance between Ca(2+) ions and Ca(2+) binding sites of helices caused widening of the distance between Ca(2+) binding sites of helices on opposite sides, while the hydrophobic side chains in the center of helices hardly moved due to their steric hindrance. This conformational change acts as the clothespin mechanism.
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