Publications by authors named "Masatomo Ishihara"
Article Synopsis
- - Loss-of-function mutations in the TET2 gene are commonly found in acute myeloid leukemia (AML) and preleukemic hematopoietic stem cells (HSCs) in older individuals.
- - The study involved creating various genetically modified mice to investigate the effects of reduced TET function on AML development, leading to three different groups: T2ΔT3, ΔT2T3, and ΔT2ΔT3.
- - The results showed that mice lacking both TET2 and TET3 (ΔT2ΔT3) died quickly from aggressive AML, while those with partial deficiencies had longer survival times, suggesting that mutations in TET genes are critical for AML progression. *
