Publications by authors named "Masato Yamadera"
Article Synopsis
- * A 64-year-old man was found to have HS affecting multiple body parts, including the lungs and bones, during a scan for colon cancer, and later showed signs of intestinal necrosis.
- * After emergency surgery to remove the necrotic intestine, the patient's postoperative recovery was smooth, but he ultimately died less than four months later due to unsuccessful chemotherapy for HS.
Article Synopsis
- - Endometriosis occurs when endometrial tissue grows outside the uterus, and intestinal endometriosis causing small bowel obstruction is rare, as seen in a 37-year-old woman who presented with abdominal pain.
- - A CT scan showed a distal small bowel obstruction, prompting surgery due to her serious condition and possible complications with conservative treatment.
- - During surgery, the diagnosis was challenging due to overlapping symptoms with bowel cancer, which necessitates careful evaluation and often leads to oncological resection.
Article Synopsis
- Tumor budding in colorectal cancer may predict patient outcomes and treatment responses, but it can't be assessed before surgery, limiting its use in treatment planning.
- A study identified high expression of four specific genes (MSLN, SLC4A11, SCEL, and MGAT3) that correlate with tumor budding grades, paving the way for better predictive models.
- A new budding predictive score was developed based on RNA levels from biopsy samples, showing strong potential for preoperative assessments.
Background: Mesothelin (MSLN) is a cell-surface glycoprotein present on mesothelial cells; its expression in several epithelial cancers generally portends an unfavorable prognosis. We investigated MSLN as a surrogate chemopredictive biomarker and examined the impact of MSLN expression in stage IV colorectal cancer (CRC).
Methods: We recruited 254 patients with CRC who received systemic chemotherapy following primary tumor resection between 2000 and 2019.
Article Synopsis
- Mesothelin (MSLN) is a protein found in mesothelial cells, and its high expression in malignant tumors, like stage III colorectal cancer (CRC), indicates a worse prognosis for patients.
- In a study involving 512 stage III CRC patients, 11.9% showed MSLN-positive tumor cells, which correlated with shorter disease-specific survival (DSS) rates, confirming MSLN as a poor prognostic factor.
- MSLN expression remained a significant predictor of poor outcomes even with chemotherapy treatment, suggesting that assessing MSLN in preoperative biopsies could help tailor more intensive chemotherapy for patients with high levels of this marker.
Article Synopsis
- Tumor budding is a significant indicator of prognosis in colon cancer (CC), and the study aimed to create a molecular budding signature (MBS) to assess its significance.
- Using frozen tissue samples from 85 colon cancer patients, researchers identified seven genes that contributed to the MBS and measured their expression levels to calculate the MBS score.
- The results showed that a higher MBS score was linked to lower relapse-free survival rates, indicating that the MBS could serve as an independent prognostic marker for determining recurrence risk in colon cancer patients.
Article Synopsis
- Recent research indicates that tumor budding is a significant prognostic factor in colorectal cancer, related to the cancer cells' ability to resist chemotherapy through epithelial-mesenchymal transition.
- This study analyzed the impact of adjuvant chemotherapy on patients with microsatellite-stable stage III colorectal cancer, focusing on those with varying tumor budding statuses across two patient cohorts.
- Results showed that patients with low-tumor budding benefited significantly from chemotherapy in terms of cancer-specific survival, whereas those with high-tumor budding did not demonstrate any significant survival advantage from the treatment.
Purpose: Cancer-induced spiculation (CIS) on computed tomography, which is reticular or linear opacification of the pericolorectal fat tissues around the cancer site, is generally regarded as cancer infiltration into T3 or T4, but its clinicopathological significance is unknown. This study examines the correlation between CIS and clinicopathological findings to establish its prognostic value.
Methods: The subjects of this retrospective study were 335 patients with colorectal cancer (CRC), who underwent curative surgery between January, 2010 and December, 2011, at the National Defense Medical College Hospital in Saitama Prefecture, Japan.
Aims: The aim of this study was to clarify the quantitative and qualitative differences in tumour budding identification between haematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for cytokeratin, and to estimate the respective clinical impacts in stage II colorectal cancer.
Methods And Results: We retrospectively examined 314 surgically resected cases of stage II colorectal cancer, and assessed tumour budding on serial section slides with H&E staining and IHC staining for cytokeratin. Tumour budding counts based on cytokeratin-stained slides were strongly correlated with those based on H&E-stained slides, and had higher detection and reproducibility.
Article Synopsis
- Sialyl Lewis (SLX) is a carbohydrate that helps cancer cells stick to blood vessel cells, playing a crucial role in the spread of cancer, specifically in stage II colorectal cancer (CRC).
- A study of 209 patients showed that higher SLX expression at the invasive front of tumors was linked to more aggressive cancer characteristics and lower disease-free survival rates.
- High SLX expression was also associated with a greater likelihood of liver cancer recurrence, making it a potential biomarker for identifying patients at higher risk.
Purpose: We conducted this study to clarify the current clinical practice of prophylactic colectomy for patients with familial adenomatous polyposis (FAP) in Japan.
Methods: This retrospective multi-center cohort study involved 23 specialized institutions for colorectal disease in Japan. We analyzed the records of 147 patients who underwent prophylactic surgical treatment between 2000 and 2012.
We report an 84-year-old woman with multiple lung metastases from sigmoid colon cancer successfully treated with an oral combination chemotherapeutic agent regimen(UFT/LV).The patient had undergone colectomy for sigmoid colon cancer. Histological examination confirmed a pT4a, pN3, pM1a(LYM), pStage IV tumor.
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- * Initially treated conservatively with improvement, he returned to the hospital 9 days later with worsened abdominal pain, prompting surgical intervention.
- * A laparoscopic partial resection revealed Crohn's disease, and the patient's post-operative recovery was positive, making this case notable for its rarity in elderly patients and use of laparoscopic surgery.