Comparative evaluation of [F]DiFA and its analogs as novel hypoxia positron emission tomography and [F]FMISO as the standard.

Introduction: Hypoxia, a common feature of most solid tumors, is an important predictor of tumor progression and resistance to radiotherapy. We developed a novel hypoxia imaging probe with optimal biological characteristics for use in clinical settings.

Methods: We designed and synthesized several new hypoxia probes with additional hydrophilic characteristics compared to [F]fluoromisonidazole ([F]FMISO).