Publications by authors named "Masato Iizuka"
Article Synopsis
- The N-MOmentum study evaluated the efficacy of inebilizumab, an anti-CD19 B cell-depleting antibody, in reducing attacks and worsening disability in NMOSD patients, including a specific focus on Asian participants.
- Subgroup analyses revealed that inebilizumab significantly lowered the risk of NMOSD attacks in the Asian group compared to placebo, with an attack-free rate of 82.1% versus 37.5% over 28 weeks.
- Overall, both Asian and non-Asian participants experienced similar NMOSD attack rates, suggesting that inebilizumab is effective across different populations despite some baseline differences.
Article Synopsis
- A compound called aldsulfin, which fights against mannheimiosis, was extracted from the fungus Lasiodiplodia pseudotheobromae FKI-4499 through a method involving bioassay-guided fractionation.
- In addition to aldsulfin, researchers also identified a known compound, lasiodipline C, during the process.
- Spectroscopic techniques like NMR, mass spectrometry, and CD analysis revealed aldsulfin's unique chemical structure and its effectiveness against the bacteria Mannheimia haemolytica and Pasteurella multocida.
An efficient synthetic route to optically pure norcantharidin analogue NCA-01, a highly selective inhibitor of protein phosphatase 2B (PP2B; calcineurin), has been developed. The absolute stereochemistry of the enantiomers was determined by X-ray crystallographic analysis. Optically pure NCA derivatives that had various substituents at the C1 position were synthesized in a similar manner.
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