Publications by authors named "Masateru Tajiri"
Article Synopsis
- * In a study of 45 ATTRv patients, NfL levels were significantly higher in symptomatic patients compared to asymptomatic carriers and controls, and there was a correlation between NfL levels and NCS parameters, particularly with CMAP and SNAP amplitudes, which indicate nerve damage.
- * NfL levels were notably elevated in patients who had undetectable amplitudes due to severe neuropathy and decreased with treatment by patisiran, suggesting that
Article Synopsis
- The article discusses a unique case of autoimmune GFAP astrocytopathy that occurred following a COVID-19 infection in a 23-year-old man who showed significant neurological symptoms two weeks after recovering from the virus.
- Symptoms included severe disorientation, headache, neck stiffness, and involuntary muscle movements, leading to his hospitalization where tests revealed low sodium levels and inflammation in the brain.
- The patient tested positive for anti-GFAPα antibodies in his cerebrospinal fluid and was successfully treated with a corticosteroid regimen, which significantly improved his condition.
Aberrant cellular accumulation of cholesterol is associated with neuronal lysosomal storage disorders such as Niemann-Pick disease Type C (NPC). We have shown previously that l-norephedrine (l-Nor), a sympathomimetic amine, induces necrotic cell death associated with massive cytoplasmic vacuolation in SH-SY5Y human neuroblastoma cells. To reveal the molecular mechanism underling necrotic neuronal cell death caused by l-Nor, we examined alterations in the gene expression profile of cells during l-Nor exposure.
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