Publications by authors named "Masataka Teranishi"
Article Synopsis
- Researchers explored the effects of transplanting human cranial bone-derived mesenchymal stem cells (hcMSCs) that were cultured in simulated microgravity (sMG) on rat models of cerebral infarction.
- The study found that hcMSCs from the sMG group improved neurological function significantly better than those from normal gravity (1G) culture, with enhanced expression of neurotrophic factors.
- RNA sequencing indicated that genes associated with cell growth, brain repair, and reduced differentiation were more active in stem cells from the sMG environment compared to the 1G group, suggesting potential benefits for recovery after stroke.
Introduction: The regulation of stem cell differentiation is important in determining the quality of transplanted cells in regenerative medicine. Physical stimuli are involved in regulating stem cell differentiation, and in particular, research on the regulation of differentiation using gravity is an attractive choice. We have shown that microgravity is useful for maintaining undifferentiated mesenchymal stem cells (MSCs).
View Article and Find Full Text PDF