Publications by authors named "Masashi Sakuramoto"
Article Synopsis
- Influenza is a major global health issue, and antiviral drugs, like baloxavir acid, can complement vaccination for prevention.
- Baloxavir acid effectively inhibits influenza virus replication, leading to lower viral levels and increased survival in mice infected with influenza A and B strains.
- The findings indicate that baloxavir marboxil could be a promising option for preventing influenza infections in humans, particularly when specific plasma drug concentrations are achieved before infection.
Dopamine exerts various effects including movement coordination and reward. It is useful to understand the quantitative relationship between drug pharmacokinetics and target engagement such as the change in occupancy and dopamine level in brain for the proper treatment of dopamine-related diseases. This study was aimed at developing a pharmacokinetic-pharmacodynamic (PK-PD) model based on dopamine transporter (DAT) occupancies that could describe changes in extracellular dopamine levels in brain after administration of methylphenidate (a DAT inhibitor) to rat.
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