Publications by authors named "Masashi Okubo"

Background: Chest compressions are life-saving in cardiac arrest but concern by layperson of causing unintentional injury to patients who are not in cardiac arrest may limit provision and therefore delay initiation when required.

Aim: To perform a systematic review of the evidence to identify if; among patients not in cardiac arrest outside of a hospital, does provision of chest compressions from a layperson, compared to no use of chest compressions, worsen outcomes.

Method: We searched Medline (Ovid), Web of Science Core Collection (clarivate) and Cinahl (Ebsco).

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Importance: Little is known about the epidemiology of out-of-hospital cardiac arrest (OHCA) in patients with asystole in countries where prehospital resuscitation is not withheld or terminated.

Objective: To investigate the secular trends in the patient outcomes and advanced life support (ALS) procedures and evaluate the association of ALS procedures with favorable outcomes among patients with OHCA and asystole.

Design, Setting, And Participants: This cohort study analyzed data from a nationwide prospective OHCA registry in Japan.

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Transition-metal oxyhydrides are an emerging class of functional materials; however, the known compounds have mostly been limited to perovskite-type sturctures. Here, we successfully synthesized LiNbHO, the first example of a rock-salt-type transition-metal oxyhydride, using mechanochemical methods. Galvanostatic charge/discharge tests revealed that LiNbHO functions as an electrode for lithium secondary batteries.

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Article Synopsis
  • The research investigated the impact of the order in which vasopressors and advanced airway management are administered during out-of-hospital cardiac arrest (OHCA) on patient outcomes, specifically looking at data from the Pragmatic Airway Resuscitation Trial (PART).
  • Out of 3,004 patients from the trial, the analysis focused on 2,404 individuals, finding no significant difference in survival rates or return of spontaneous circulation based on whether vasopressors or advanced airway interventions were performed first.
  • The study concluded that the sequence of administering vasopressors and airway management did not affect patient outcomes or the quality of CPR delivered during resuscitation efforts.
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  • All-solid-state batteries utilize nonflammable inorganic solid electrolytes to enhance safety compared to traditional lithium-ion batteries that use flammable liquid electrolytes.
  • Conventional electrode materials face significant volume changes during lithium ion movement, leading to mechanical failures and reduced performance.
  • This study introduces MXenes, which maintain structural stability during lithium (de)intercalation, resulting in a strain-free solid-state battery that shows improved long-term stability and maintains effective interface contact between the electrodes and solid electrolytes.
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Objective: To develop a translation between the Glasgow Come Scale and the Alert-Verbal-Pain-Unresponsive (AVPU) scale among adults with out-of-hospital emergencies.

Methods: We performed a retrospective analysis of adults (≥18 years) from the 2022 National Emergency Medical Services (EMS) Information System with a ground scene encounter with a concurrently documented GCS and AVPU assessment. Using a training partition of 2.

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Managing safety and supply-chain risks associated with lithium-ion batteries (LIBs) is an urgent task for sustainable development. Aqueous proton batteries are attractive alternatives to LIBs because using water and protons addresses these two risks. However, most host materials undergo large volume changes upon H intercalation, which induces intraparticle cracking to accelerates parasitic reactions.

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  • This study compares the effectiveness of two strategies for pediatric out-of-hospital cardiac arrest (OHCA): intra-arrest transport (moving a patient to the hospital during CPR) versus continuing on-scene CPR until the resuscitation effort is complete.
  • The research analyzes data from pediatric patients treated by EMS from 2005 to 2015, with a focus on how these strategies impact survival rates after cardiac arrest.
  • Findings reveal that 66.3% of the children underwent intra-arrest transport, and the study aims to determine if survival outcomes differ based on the timing of transport and patient age.
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Pseudocapacitance is capable of both high power and energy densities owing to its fast chemical adsorption with substantial charge transfer. 2D transition-metal carbides/nitrides (MXenes) are an emerging class of pseudocapacitive electrode materials. However, the factors that dominate the physical and chemical properties of MXenes are intercorrelated with each other, giving rise to challenges in the quantitative assessment of their discriminating importance.

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Objective: National guidelines in the United States recommend the intramuscular and intranasal routes for midazolam for the management of seizures in the prehospital setting. We evaluated the association of route of midazolam administration with the use of additional benzodiazepine doses for children with seizures cared for by emergency medical services (EMS).

Methods: We conducted a retrospective cohort study from a US multiagency EMS dataset for the years 2018-2022, including children transported to the hospital with a clinician impression of seizures, convulsions, or status epilepticus, and who received an initial correct weight-based dose of midazolam (.

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  • The study investigates the role of prehospital systemic corticosteroid administration by EMS clinicians in treating asthma exacerbations, particularly its effects on hospitalization and length of stay in the hospital.
  • Researchers analyzed data from over 15,000 EMS encounters, finding that nearly 30% of patients received corticosteroids before reaching the hospital, with several factors influencing administration rates.
  • The results suggested that while prehospital corticosteroid use did not significantly reduce overall hospitalization or length of stay, it showed potential benefits for specific patient groups during longer EMS encounters and those with certain symptoms like wheezing.
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  • The study investigates the best sequence for administering epinephrine and advanced airway management (AAM) during out-of-hospital cardiac arrest (OHCA) to determine its impact on patient survival outcomes.
  • Conducted on a large cohort from a national OHCA registry in Japan, the research focused on adults aged 18 and older who received either or both treatments from emergency services between 2014 and 2019.
  • Results showed that patients who received epinephrine before AAM had significantly better survival rates after one month, regardless of whether their initial heart rhythm was shockable or nonshockable.
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  • The study aimed to analyze how the duration of cardiopulmonary resuscitation (CPR) affects outcomes for patients who experience in-hospital cardiac arrest, focusing on survival rates and health status upon discharge.
  • It was a retrospective cohort analysis involving nearly 349,000 adult patients who underwent CPR between 2000 and 2021 in a multicenter US registry, examining the relationship between CPR duration and the likelihood of survival and functional recovery.
  • Key findings revealed that 66.9% of patients achieved return of spontaneous circulation after a median of 7 minutes of CPR, while 22.6% ultimately survived to discharge, highlighting the critical role of timely and continued resuscitation efforts.
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Background: Vital signs are a critical component of the prehospital assessment. Prior work has suggested that vital signs may vary in their distribution by age. These differences in vital signs may have implications on in-hospital outcomes or be utilized within prediction models.

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Background: Patients resuscitated from cardiac arrest have variable severity of primary hypoxic ischemic brain injury (HIBI). Signatures of primary HIBI on brain imaging and electroencephalography (EEG) include diffuse cerebral edema and burst suppression with identical bursts (BSIB). We hypothesize distinct phenotypes of primary HIBI are associated with increasing cardiopulmonary resuscitation (CPR) duration.

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Importance: While epinephrine has been widely used in prehospital resuscitation for pediatric patients with out-of-hospital cardiac arrest (OHCA), the benefit and optimal timing of epinephrine administration have not been fully investigated.

Objectives: To evaluate the association between epinephrine administration and patient outcomes and to ascertain whether the timing of epinephrine administration was associated with patient outcomes after pediatric OHCA.

Design, Setting, And Participants: This cohort study included pediatric patients (<18 years) with OHCA treated by emergency medical services (EMS) from April 2011 to June 2015.

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Article Synopsis
  • The ILCOR Research and Registries Working Group updated data on out-of-hospital cardiac arrest (OHCA) trends from 2015-2017 using information from 11 national and 4 regional registries worldwide.
  • A total of 30.0-97.1 EMS-treated OHCAs per 100,000 population were reported annually, with bystander CPR rates ranging from 37.2% to 79.0% in 2015, improving slightly in subsequent years.
  • While there was a general increase in bystander CPR, overall survival rates to hospital discharge remained low, with only 16.4% survival in the best cases by 2017, indicating significant variability across different
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The local structures of Ti based MXene-type electrode materials have been studied by Ti K-edge X-ray absorption fine structure measurements as a function of temperature to obtain direct information on the local bond lengths and their stiffness. In particular, the parent MAX phases TiAlC and TiAlC and their etched MXene systems are characterized and their properties compared. We find that selective etching has a substantial effect on the local structural properties of the Ti based MXene materials.

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It is desirable for secondary batteries to have high capacities and long lifetimes. This paper reports the use of Na FeS with a specific structure consisting of edge-shared and chained FeS as the host structure and as a high-capacity active electrode material. An all-solid-state sodium cell that uses Na FeS exhibits a high capacity of 320 mAh g , which is close to the theoretical two-electron reaction capacity of 323 mAh g , and operates reversibly for 300 cycles.

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Developing high-power battery chemistry is an urgent task to buffer fluctuating renewable energies and achieve a sustainable and flexible power supply. Owing to the small size of the proton and its ultrahigh mobility in water via the Grotthuss mechanism, aqueous proton batteries are an attractive candidate for high-power energy storage devices. Grotthuss proton transfer is ultrafast owing to the hydrogen-bonded networks of water molecules.

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The Mn 3d electronic-structure change of the LiMnO cathode during Li-ion extraction/insertion in an aqueous electrolyte solution was studied by resonant soft X-ray emission spectroscopy (RXES). The Mn L RXES spectra for the charged state revealed the Mn state with strong charge-transfer from the O 2p to Mn 3d orbitals dominates, while for the open-circuit-voltage and discharged states it is ascribed to the mixture of sites with Mn and Mn states. The degree of charge transfer is significantly different between the Mn and Mn states, indicating that the redox reaction takes place on the strongly-hybridized Mn 3d-O 2p orbital rather than the localized Mn 3d orbital.

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Objective: Clinical trials for patients with shock-refractory out-of-hospital cardiac arrest (OHCA), including the Amiodarone, Lidocaine or Placebo (ALPS) trial, have been unable to demonstrate definitive benefit after treatment with antiarrhythmic drugs. A Bayesian approach, combining the available evidence, may yield additional insights.

Methods: We conducted a reanalysis of the ALPS trial comparing treatment with amiodarone or lidocaine with placebo in patients with OHCA following shock-refractory ventricular fibrillation or ventricular tachycardia (VF/VT).

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Aqueous lithium-ion batteries are promising electrochemical energy storage devices owing to their sustainable nature, low cost, high level of safety, and environmental benignity. The recent development of a high-salt-concentration strategy for aqueous electrolytes, which significantly expands their electrochemical potential window, has created attractive opportunities to explore high-performance electrode materials for aqueous lithium-ion batteries. This study evaluates the compatibility of large-capacity oxygen-redox cathodes with hydrate-melt electrolytes.

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