Publications by authors named "Masashi Matsushima"
Article Synopsis
- Amoebic dysentery is a serious disease in Japan, classified as Category 5, with around 1,000 annual cases, and about 10% are invasive strains.
- Most invasive cases show no symptoms, making them hard to detect, especially since a key blood test was discontinued in 2017.
- Proper diagnosis and treatment are crucial to avoid severe complications, such as ulceration and liver abscesses, which can occur with delayed care.
Ulcerative colitis (UC) has been associated with increased prostate cancer (PCa) risk. However, the mechanisms underlying UC and increased PCa risk remain unclear, and research on this topic is scarce in Japan. We have investigated whether UC is associated with PCa risk in the Japanese population and the risk factors related to PCa among older UC patients.
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- Misdiagnosing intestinal tuberculosis (ITB) as Crohn's disease (CD) can have serious consequences, especially when treated with immunosuppressive therapies.
- A case study is presented of a patient from Myanmar who was initially diagnosed with CD but worsened on steroids, leading to a later diagnosis of ITB.
- Understanding the epidemiological context of countries like Myanmar, where tuberculosis is common, is crucial for differentiating between CD and ITB effectively.
Article Synopsis
- A study was conducted to evaluate the effectiveness and safety of Capecitabine plus oxaliplatin (CapeOX) as a first-line treatment for advanced gastric cancer in patients aged 70 years and older.
- The trial included 108 chemotherapy-naive patients, who were given either the original or reduced doses of CapeOX, with overall survival (OS) being the primary measurement.
- Results showed a median OS of 12.9 months, with some patients experiencing significant side effects, mainly neutropenia and anemia, indicating that CapeOX is a viable treatment option for older patients with advanced gastric cancer.
Article Synopsis
- AIEC, a pathobiont linked to Crohn's disease, thrives in inflammatory conditions and is believed to worsen the disease, yet how the immune system reacts to it remains poorly understood.
- Researchers used antibiotic-treated mice to study how the immune system produces IgA antibodies against AIEC following colonization, while examining IgA binding to various strains.
- The findings indicate that IgA specifically recognizes AIEC, which helps prevent its invasion into the epithelial cells of the colon, suggesting a protective role of IgA in combating this pathobiont.
Article Synopsis
- - Breast cancer is a common type of cancer in women and can spread to various parts of the body, with gastrointestinal tract metastasis being rare.
- - Invasive lobular carcinoma, a less common form of breast cancer, has a higher likelihood of metastasizing to the gastrointestinal tract compared to invasive ductal carcinoma.
- - The text discusses a rare case of invasive lobular carcinoma that extensively metastasized to the colonic mucosa and highlights the potential increase in rare metastatic diseases due to better survival rates from current treatments.
Transarterial embolization (TAE) is performed in patients with colonic diverticular bleeding after difficult endoscopic hemostasis or rebleeding. A total of 375 patients with hematochezia at our hospital from 1 April 2016 to 31 March 2020 were retrospectively analysed. Firstly, we compared the group in which hemostasis was achieved by endoscopy alone with the group that eventually underwent TAE.
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- Patients with inflammatory bowel disease (IBD), specifically those with ulcerative colitis (UC) and Crohn's disease (CD), frequently experience oral health issues like periodontitis, yet its impact on gut inflammation is poorly understood.
- A study involving 60 IBD patients and 45 healthy controls revealed that the gut microbiome of IBD patients was more similar to their oral microbiome, indicating an increased colonization of gut bacteria by oral bacteria.
- While early periodontitis didn't significantly alter clinical outcomes for most IBD patients, it was associated with a worsening activity index in some CD patients, suggesting it could exacerbate symptoms in certain cases.
Intracholecystic papillary neoplasms are newly defined precancerous lesions. According to Classification of the World Health Organization, they have four histological morphologies, which are biliary, gastric, intestinal, and oncocytic. This study evaluated 17 patients with resected intracholecystic papillary neoplasms in terms of histological, immunohistochemical, and copy number variation (CNV).
View Article and Find Full Text PDFBackground: The effects of the type of anesthesia (spinal (SA) vs. general (GA)) used for transurethral resection of bladder tumor (TURBT) on non-muscle invasive bladder cancer (NMIBC) recurrence and progression are controversial and our aim is to investigate their associations.
Methods: We identified 300 NMIBC patients who underwent initial TURBT with SA or GA.
The risk of carcinogenesis increases after 20 years old in patients with Fanconi anemia (FA). We herein report three rare cases of FA combined with esophageal cancer in women; all patients were diagnosed with FA in early childhood. Patients 1 and 2 were diagnosed with advanced and superficial esophageal cancer, respectively, at 21 and 30 years old, respectively.
View Article and Find Full Text PDFAt 37 years old, a patient developed chronic watery diarrhea, generalized pain, severe hypokalemia and elevated creatine kinase levels. She was thought to have rhabdomyolysis due to hypokalemia from chronic diarrhea. No organic cause was found.
View Article and Find Full Text PDFObjectives: To investigate the relationship between radiation doses in prostate brachytherapy and deterioration of erectile function in patients with localized prostate cancer.
Methods: A longitudinal survey study was carried out among 261 prostate cancer patients who received prostate brachytherapy. A total of 48 patients were potent at baseline and they did not receive any supplemental therapy preoperatively.
Purpose: To evaluate the oncological feasibility of pure laparoscopic radical nephroureterectomy (p-LRNU) for upper tract urothelial carcinoma (UTUC) compared with conventional LRNU (c-LRNU) using a propensity-adjusted multi-institutional collaboration dataset.
Methods: Among the 503 UTUC patients who underwent RNU, we identified 219 who underwent c-LRNU (laparoscopic nephrectomy with open bladder cuff resection) and 72 who underwent p-LRNU (dissecting the kidney, ureter, and bladder cuff under complete laparoscopy). We adopted a propensity score (PS) matching method to achieve homogeneity with respect to patient backgrounds.
Introduction: Lipopolysaccharides (LPSs) of Gram-negative bacteria (GNB) are highly toxic and induce inflammation. Therefore, we investigated both the LPS activity and composition of GNB in the gastric fluid (GF) to assess the potential toxicity of them accumulated in the stomach.
Methods: GF and saliva samples were obtained from 158 outpatients who were undergoing upper gastrointestinal endoscopy and 36 volunteers using a nasogastric tube.
Article Synopsis
- Foreign body ingestion is common in emergency settings, but cases with multiple sharp objects in various organs are rare and lack established treatment guidelines.
- A 31-year-old magician experienced epigastric discomfort after possibly swallowing needles during a trick; imaging revealed needles in the liver, duodenum, and colon.
- Successful removal of most needles was achieved through endoscopy and laparoscopy, and the patient was discharged without complications after four days, highlighting the need for teamwork among medical specialists in such complex cases.
Article Synopsis
- Intestinal fibrosis is a significant issue in Crohn's disease, primarily driven by the protein transforming growth factor-β (TGF-β), which promotes collagen and plasminogen activator inhibitor-1 (PAI-1) production, contributing to ECM buildup.
- The study involved inducing chronic intestinal inflammation in mice and administering TM5275, a PAI-1 inhibitor, which showed promise in reducing collagen accumulation and promoting collagen degradation.
- The findings suggest that targeting PAI-1 could offer a new treatment strategy for managing intestinal fibrosis in Crohn's disease patients.
Article Synopsis
- The study focused on understanding the immune environment in Ulcerative Colitis (UC) and how it relates to the need for second-line steroid therapy within two years after diagnosis.
- It involved analyzing tissue samples from 72 cases, comparing normal mucosa to UC cases, as well as looking at differences between patients requiring steroid therapy and those who did not.
- Findings revealed that UC had increased immune markers and lower BTLA levels compared to normal tissues, and that those requiring steroids showed significant differences in specific immune cell populations, suggesting immune imbalance plays a role in UC and its treatment needs.
A 95-year-old man was admitted to the hospital due to a sudden onset of nausea and abdominal pain. Physical examination revealed abdominal distension with mild epigastric tenderness. Computed tomography showed a grossly distended stomach with displacement of the antrum above the esophago-gastric junction, and he was diagnosed with acute mesentero-axial gastric volvulus.
View Article and Find Full Text PDFObjective: Ischemic colitis (IC) is a relatively common acute inflammation disorder of the intestine. It was considered to be a disorder of elderly people with risk factors for arteriosclerosis; however, a considerable number of young people with IC have been reported recently. We performed a case-control study to determine the risk factors for IC and compare the risk factors between elderly and non-elderly people.
View Article and Find Full Text PDFObjective: To investigate the influence of antimicrobials on both the gut microbiota structure and the plasma ghrelin level using -infected patients who underwent eradication therapy.
Design: Twenty -infected patients (mean age 68.3 years old) who underwent eradication therapy participated in the study.
Leiomyoma is one of the most commonly observed esophageal submucosal tumors, often appearing as a smooth-surfaced and semicircular protruded lesion. It sometimes grows toward the esophageal lumen and may be pedunculated in rare cases. We encountered a case of a pedunculated esophageal submucosal tumor diagnosed before treatment as a leiomyoma originating in the muscularis mucosae of a 68-year-old man.
View Article and Find Full Text PDFBackground: Detailed information is not currently available on the incidence, natural course, and management of asymptomatic abnormal prostate findings incidentally detected by radiologic evaluations after BCG therapy for non-muscle-invasive bladder cancer patients.
Methods: We identified 38 patients who were evaluated by contrast-enhanced CT scans before TUR-BT and after BCG therapy between 2006 and 2012. We evaluated the clinical courses of patients with abnormal radiologic findings of the prostate gland after BCG therapy.
Article Synopsis
- A study investigated the effects of the probiotic Lactobacillus gasseri OLL2716 (LG) on small bowel injuries caused by aspirin in 64 patients who had been taking aspirin for over a month.
- Patients consumed yogurt with LG or a placebo for 6 weeks, with small bowel injuries evaluated before and after using capsule endoscopy.
- Results showed that the LG group had significantly fewer injuries and improved gastrointestinal symptoms compared to the placebo group, suggesting LG could help reduce aspirin-induced gut issues.
Objective: The relationship between endogenous creatinine clearance (eCrCl) and renal function values obtained using mathematical formulas has not yet been fully elucidated, especially in patients with upper tract urothelial carcinoma that are treated with radical nephroureterectomy followed by cisplatin-based chemotherapy.
Methods: Sixty patients who received cisplatin-based chemotherapy for locally advanced or metastatic upper tract urothelial carcinoma after radical nephroureterectomy between 2000 and 2012 were retrospectively identified. eCrCl was measured based on 24-hour urine specimens obtained immediately prior to each cycle of chemotherapy.