Publications by authors named "Masashi Kuroki"
Background: Previously, we proposed that the immune-modified Glasgow Prognostic Score (imGPS), which adds the lymphocyte count to the mGPS, is helpful as a prognostic marker for patients with head and neck squamous cell carcinoma. In this study, we investigated the imGPS as a marker for the therapeutic effect of pembrolizumab in treating recurrent and metastatic head and neck cancer (RMHNC).
Methods: This study included RMHNC patients who were treated with pembrolizumab from December 2019 to April 2024.
Objective: To distinguish squamous cell carcinoma in inverted papilloma (IP-SCC) from IP, the utility of CT scoring system was investigated.
Methods: We extracted cases histopathologically diagnosed with IP and IP-SCC of the sinonasal cavity from June 2004 to May 2021. Preoperative unenhanced CT images were used to evaluate the presence or absence of bone destruction and erosion: Score 1 = positive for bone destruction and/or erosion; Score 0 = negative for bone destruction and erosion.
Article Synopsis
- Transoral surgery is effective for early-stage pharyngeal and laryngeal cancer, offering good local control with less invasiveness compared to external incisions, but criteria for postoperative treatment remain unclear.
- In a study of 70 patients at Gifu University Hospital, high rates of positive surgical margins were found (38.6% horizontal, 27.1% vertical), yet overall survival rates were strong, with 77.1% surviving five years post-surgery.
- Horizontal margin positivity correlated with worse outcomes, while vascular invasion wasn't significantly linked to prognosis, indicating a need for more research to establish clear postoperative treatment guidelines.
Objective: Head and neck cancer (HNC) is a tumor occurring in various primary sites with limited chemotherapy options for its treatment. Recently, comprehensive genomic profiling (CGP) testing has become clinically widespread. In this study, we examined the utility of CGP in diagnosing and treating HNC.
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- * The surgical removal of the metastatic lymph node involved the resection of nutrient vessels; however, the jejunum remained viable and did not become necrotic, suggesting that certain indicators can predict transplant survival post-surgery.
- * Key survival indicators include monitoring jejunal blood flow using indocyanine green fluorescence imaging and observing jejunal color and movement, which could potentially help surgeons determine the future health of the transplanted jejunum after vessel resection.
Perioperative blindness, especially posterior ischemic optic neuropathy (PION), is an uncommon but potentially devastating complication. We report a case of a 65-year-old male patient who underwent laryngopharyngectomy, bilateral neck dissection, and free jejunum flap reconstruction, but then experienced PION in his right eye following postoperative bleeding and bilateral internal jugular veins (IJVs) compression. Despite systemic corticosteroid therapy, his visual recovery prognosis was poor.
View Article and Find Full Text PDFCarcinoma showing thymus-like differentiation (CASTLE) is a rare malignant tumor that originates from ectopic thymic or residual embryonic tissues. CASTLE is specified as a synonym for intrathyroidal thymic carcinoma. The patient is a 66-year-old male.
View Article and Find Full Text PDFSignet-ring cell/histiocytoid carcinoma (SRCHC) is a rare, aggressive neoplasm that often originates in the eyelid. We present a rare case of a 64-year-old male with SRCHC and papillary thyroid carcinoma (PTC) that underwent exome panel sequencing with next-generation sequencing (NGS). In addition, we reviewed reports of genetic mutations in SRCHC and compared them with our results.
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